Abstract | OBJECTIVE: The success of an amylin analogue in weight loss trials has generated interest in amylin as a physiological satiety signal. Little is known about how plasma amylin responds to macronutrients. This study examined the effects of a high- carbohydrate meal (CHO), a high-fat meal (FAT) or a continued fast (FAST) on amylin concentrations and correlations among other satiety hormones and measures of appetite. DESIGN/PATIENTS: In a randomized, crossover design, 10 healthy males consumed a meal high in carbohydrate or fat or continued fasted. MEASUREMENTS: Blood samples and subjective hunger scores were obtained at baseline and 30, 90 and 210 min postprandial. RESULTS: After CHO, amylin, insulin and C-peptide were greater and des-acyl ghrelin lower compared to FAT (P < 0.001). Area under the curve (AUC) was greater for amylin and insulin and lower for des-acyl ghrelin following CHO. Subjective satiety and fullness were higher for CHO and FAT than FAST at 30 and 90 min but only for CHO at 210 min (P < 0.01). Hunger and desire to eat were lower for CHO and FAT than FAST at 30 and 90 min but only for CHO at 210 min (P < 0.005). Amylin was negatively correlated to hunger, desire to eat, and nausea and positively related to satiety and insulin. Des-acyl ghrelin was negatively associated with C-peptide, insulin and GLP-1 and satiety. CONCLUSIONS: CHO enhances amylin and suppresses des-acyl ghrelin to a greater extent than FAT in healthy men. The mechanisms responsible for these changes and their implications in the physiology of satiety remain to be elucidated.
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Authors | Lindsay K Eller, Philip N Ainslie, Marc J Poulin, Raylene A Reimer |
Journal | Clinical endocrinology
(Clin Endocrinol (Oxf))
Vol. 68
Issue 6
Pg. 890-7
(Jun 2008)
ISSN: 1365-2265 [Electronic] England |
PMID | 18031323
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Amyloid
- Blood Glucose
- C-Peptide
- Dietary Carbohydrates
- Dietary Fats
- Ghrelin
- Insulin
- Islet Amyloid Polypeptide
- Glucagon-Like Peptide 1
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Topics |
- Adult
- Amyloid
(blood)
- Area Under Curve
- Blood Glucose
- C-Peptide
(blood)
- Cross-Over Studies
- Dietary Carbohydrates
(pharmacology)
- Dietary Fats
(pharmacology)
- Ghrelin
(blood)
- Glucagon-Like Peptide 1
(blood)
- Humans
- Hunger
- Insulin
(blood)
- Islet Amyloid Polypeptide
- Male
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