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Blocking weight-induced spinal cord injury in rats: therapeutic effect of the 21-aminosteroid U74006F.

Abstract
The effect of the 21-aminosteroid U74006F on neurologic recovery after a spinal cord compression trauma was investigated in rats. The compression was induced by a blocking weight technique, in which a 35 g (moderate injury) or a 50 g (severe injury) weight was applied for 5 minutes to an 11 mm2 plate over the midthoracic spinal cord. One hour after trauma, the severely injured animals were treated either with U74006F, 3 mg/kg, methylprednisolone, 30 mg/kg, or vehicle, whereas the moderately injured animals received U74006F, 3 mg/kg or vehicle. Neurologic hind limb function was evaluated by the inclined plane technique. On day 1 after trauma, subtotal paraparesis occurred in the 35 g group treated with vehicle (31 +/- 1 degrees, mean +/- SEM) on the inclined plane vs 64 +/- 1 degrees before trauma) and complete paraplegia in the 50 g group (22 +/- 1 degrees). Treatment with U74006F resulted in less hind limb weakness in the 35 g group (42 +/- 2 degrees) but had no beneficial effect in the 50 g group (25 +/- 2 degrees). Neurologic function gradually improved in the 35 g groups over the 9-day observation period. However, those animals treated with U74006F were significantly better over the entire period. In the 50 g group, no recovery from paraplegia was noted over the 4 day observation period in any of the three groups. These results suggest that after weight-induced spinal cord trauma, U74006F is associated with improved neurologic function in moderately injured, but not severely injured animals.
AuthorsA Holtz, B Gerdin
JournalJournal of neurotrauma (J Neurotrauma) Vol. 8 Issue 4 Pg. 239-45 ( 1991) ISSN: 0897-7151 [Print] United States
PMID1803032 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Lipid Peroxides
  • Pregnatrienes
  • Methylprednisolone
  • tirilazad
Topics
  • Animals
  • Hindlimb (physiology)
  • Lipid Peroxides (antagonists & inhibitors)
  • Male
  • Methylprednisolone (therapeutic use)
  • Paraplegia (physiopathology)
  • Pregnatrienes (therapeutic use)
  • Psychomotor Performance (drug effects)
  • Rats
  • Rats, Inbred Strains
  • Spinal Cord Compression (drug therapy, physiopathology)

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