| Abstract | The effect of the 21-aminosteroid U74006F on neurologic recovery after a spinal cord compression trauma was investigated in rats. The compression was induced by a blocking weight technique, in which a 35 g (moderate injury) or a 50 g (severe injury) weight was applied for 5 minutes to an 11 mm2 plate over the midthoracic spinal cord. One hour after trauma, the severely injured animals were treated either with U74006F, 3 mg/kg, methylprednisolone, 30 mg/kg, or vehicle, whereas the moderately injured animals received U74006F, 3 mg/kg or vehicle. Neurologic hind limb function was evaluated by the inclined plane technique. On day 1 after trauma, subtotal paraparesis occurred in the 35 g group treated with vehicle (31 +/- 1 degrees, mean +/- SEM) on the inclined plane vs 64 +/- 1 degrees before trauma) and complete paraplegia in the 50 g group (22 +/- 1 degrees). Treatment with U74006F resulted in less hind limb weakness in the 35 g group (42 +/- 2 degrees) but had no beneficial effect in the 50 g group (25 +/- 2 degrees). Neurologic function gradually improved in the 35 g groups over the 9-day observation period. However, those animals treated with U74006F were significantly better over the entire period. In the 50 g group, no recovery from paraplegia was noted over the 4 day observation period in any of the three groups. These results suggest that after weight-induced spinal cord trauma, U74006F is associated with improved neurologic function in moderately injured, but not severely injured animals. |
| Authors | A Holtz, B Gerdin
(Affiliation: Department of Neurosurgery, University Hospital, Uppsala, Sweden.)
|
| Journal | Journal of neurotrauma
(J Neurotrauma)
Vol. 8
Issue 4
Pg. 239-45
( 1991)
ISSN: 0897-7151 UNITED STATES |
| PMID | 1803032
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Lipid Peroxides
- Pregnatrienes
- tirilazad
- Methylprednisolone
|
| Topics |
- Animals
- Hindlimb
(physiology)
- Lipid Peroxides
(antagonists & inhibitors)
- Male
- Methylprednisolone
(therapeutic use)
- Paraplegia
(physiopathology)
- Pregnatrienes
(therapeutic use)
- Psychomotor Performance
(drug effects)
- Rats
- Rats, Inbred Strains
- Spinal Cord Compression
(drug therapy, physiopathology)
|
