Abstract | PURPOSE:
Potassium release from blood cells is a contrast medium-induced phenomenon. The purposes of the study were to (1) assess the effect of hyperosmolality and of adding sodium ions and calcium ions to a solution on potassium release from human blood cells and (2) reevaluate the possibility of hemolysis as a cause of potassium elevation. MATERIALS AND METHODS: RESULTS: Hyperosmolality using glucose solutions promoted higher potassium release. The average +/- SD potassium release rates were 7.3 +/- 2.4 micromol/min with 5% glucose, 13.5 +/- 2.3 micromol/min with 20% glucose, and 128.4 +/- 44.9 micromol/min with 50% glucose. The solutions including sodium ions showed lower release rates. The addition of sodium and calcium ions into 50% glucose significantly lowered the potassium release rates. No significant elevation of GOT or LDH was observed, and the possibility of hemolysis was eliminated. CONCLUSION:
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Authors | Katsumi Hayakawa, Tatsuo Nakamura, Yasuhiko Shimizu |
Journal | Radiation medicine
(Radiat Med)
Vol. 25
Issue 9
Pg. 467-73
(Nov 2007)
ISSN: 0288-2043 [Print] Japan |
PMID | 18026905
(Publication Type: Journal Article)
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Chemical References |
- Contrast Media
- Sodium
- Glucose
- Potassium
- Calcium
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Calcium
(pharmacology)
- Contrast Media
(pharmacology)
- Female
- Glucose
(pharmacology)
- Humans
- In Vitro Techniques
- Least-Squares Analysis
- Linear Models
- Male
- Middle Aged
- Osmolar Concentration
- Potassium
(blood)
- Sodium
(pharmacology)
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