Plasma concentration of heat shock protein 27 and risk of cardiovascular disease: a prospective, nested case-control study.
|
| Abstract | BACKGROUND: Heat shock protein 27 (HSP27) has been hypothesized to be a potential biomarker of atherothrombosis. However, no prospective studies have yet been performed to investigate the association between HSP27 plasma concentration and incident cardiovascular events among initially healthy individuals. METHODS: We evaluated plasma concentrations of HSP27 at baseline among 255 initially healthy participants in the Women's Health Study who subsequently developed myocardial infarction, ischemic stroke, or cardiovascular death during a follow-up period of up to 5.9 years and among an equal number of women matched for age and smoking but who remained free of cardiovascular disease over the same time period. RESULTS: Overall, HSP27 plasma concentrations were inversely associated with age (Spearman correlation coefficient r = -0.258, P <0.001), but not with other established cardiovascular risk factors. Conditional logistic regression analysis showed no significant association of baseline HSP27 plasma concentration with future cardiovascular disease; the odds ratio for upper vs lower tertile of HSP27 concentration at baseline was 0.99 (95% CI 0.62-1.57, P for trend = 0.99). CONCLUSION: In this prospective study of initially healthy women, baseline HSP27 plasma concentration was not associated with incident cardiovascular events. |
|---|---|
| Authors | Isabella Kardys, Nader Rifai, Olivier Meilhac, Jean-Baptiste Michel, Jose Luis Martin-Ventura, Julie E Buring, Peter Libby, Paul M Ridker (Affiliation: Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, 900 Commonwealth Avenue East, Boston, MA 02215, USA. i.kardys at erasmusmc.nl) |
| Journal | Clinical chemistry (Clin Chem) Vol. 54 Issue 1 Pg. 139-46 (Jan 2008) ISSN: 0009-9147 [Print] United States |
| PMID | 18024525 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't) |
| Chemical References |
|
| Topics |
|
Join CureHunter, for free Research Interface BASIC access!
Realize the full power of the drug-disease research network!
Research Interface PRO additionally includes drill-down to evidence, articles by author, export to Excel, FDA Link and mobile subscription:
1 year subscription, $45.00 USD
