Clinical features and outcomes of 134 Brazilians with acute promyelocytic leukemia who received ATRA and anthracyclines.

Abstract	We report an increased incidence of high relapse risk features in 157 APL Brazilian patients. Out of 134 patients treated with ATRA and anthracyclines, only 91 (67.9%) achieved remission because 43 (32%) died during induction. The death rate during consolidation was 10.5%. Bleeding complications were the most frequent cause of failure (21.6%).
Authors	Rafael Henriques Jácomo, Raul Antonio Morais Melo, Fernanda Ribeiro Souto, Ederson Roberto de Mattos, Claudia Teresa de Oliveira, Evandro M Fagundes, Henrique Neves da Silva Bittencourt, Rosane Isabel Bittencourt, Teresa Cristina Bortolheiro, Eduardo J A Paton, Rodrigo Bendlin, Sebastião Ismael, Maria de Lourdes Chauffaille, Dirceu Silva, Katia Borgia B Pagnano, Raul Ribeiro, Eduardo M Rego
Journal	Haematologica (Haematologica) Vol. 92 Issue 10 Pg. 1431-2 (Oct 2007) ISSN: 1592-8721 [Electronic] Italy
PMID	18024380 (Publication Type: Letter)
Chemical References	Anthracyclines Tretinoin
Topics	Adolescent Adult Aged Anthracyclines (therapeutic use) Brazil (epidemiology) Child Child, Preschool Drug Therapy, Combination Female Follow-Up Studies Humans Leukemia, Promyelocytic, Acute (drug therapy, epidemiology, pathology) Male Middle Aged Treatment Outcome Tretinoin (therapeutic use)

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