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[Melittin inhibits proliferation and induces apoptosis of malignant human glioma cells].

AbstractOBJECTIVE:
To investigate the anti-tumor effects of melittin against malignant human glioma cells in vitro.
METHODS:
Two malignant human glioma cell lines (U87 and U251) were treated with melittin at various concentrations, and the cell growth inhibition and apoptosis were evaluated using MTT assay, flow cytometry and agarose gel electrophoresis.
RESULTS:
Melittin could obviously inhibit the proliferation of the two glioma cell lines (P<0.05). At the concentrations of 1, 10, 20, 40, 80, 160, 200 mg/L, melittin resulted in U87 cell apoptosis rates of 12.80%, 16.92%, 22.69%, 34.05%, 41.82%, 59.87%, and 80.25%, and in U251 cell apoptosis rate of 11.61%, 16.21%, 22.03%, 30.57%, 41.10%, 58.33%, and 79.12%, respectively, showing a dose-dependent effect in its action of inducing cell apoptosis.
CONCLUSION:
Melittin inhibits the proliferation and induces apoptosis of malignant human glioma cell lines in vitro.
AuthorsZhi-lin Yang, Yi-quan Ke, Ru-xiang Xu, Ping Peng
JournalNan fang yi ke da xue xue bao = Journal of Southern Medical University (Nan Fang Yi Ke Da Xue Xue Bao) Vol. 27 Issue 11 Pg. 1775-7 (Nov 2007) ISSN: 1673-4254 [Print] China
PMID18024312 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Melitten
Topics
  • Apoptosis (drug effects)
  • Cell Line, Tumor
  • Cell Proliferation (drug effects)
  • Glioma (metabolism, pathology)
  • Humans
  • Melitten (pharmacology)

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