| Abstract | OBJECTIVE: To evaluate seizure outcome following epilepsy surgery for patients with temporal lobe epilepsy and evaluate is gender and race/ethnicity influence it. METHODS: Data were obtained from the discharge database of the University of Alabama at Birmingham, Epilepsy Center, between 1985 and 2001. The sample consisted of all patients with a primary diagnosis of medically intractable temporal lobe epilepsy (TLE) who underwent anterior temporal lobectomy. Seizure recurrence was tabulated at 7 days, 2 months, 6 months, 1, 2, 3, 4, 5, and 6 years following surgery. Logistic regression analysis was used to model the presence of seizure recurrence after anterior temporal lobectomy for all patients. Kaplan-Meier analysis was done to obtain estimates and 95% CIs of seizure freedom from baseline. Baseline variables--age at surgery, age at seizure onset, sex, side of resection, immediate postoperative seizures, and pathology results--were assessed as potential predictors of each outcome by comparing the survival curves within each variable with a log rank test. RESULTS: Three hundred sixty-eight patients underwent surgical treatment for TLE, mean age of 30.2 years. Thirty-five patients were African American, 43% were men. Immediate postoperative seizures were seen in 23 patients, while seizure recurrence occurred in 27.3% patients within a year after surgery, and in 33.6% within 6 years. Logistic regression results showed no differences between African Americans and whites, between males and females. The occurrence of immediate postoperative seizures was a strong predictor of late seizure recurrence only at 1 year after surgery. CONCLUSIONS: The occurrence of seizures in the immediate postoperative period is a strong predictor of later seizure recurrence. Sex and race/ethnicity do not appear to be predictors of long-term outcome following surgery for temporal lobe epilepsy. |
| Authors | Jorge G Burneo, Vicente Villanueva, Robert C Knowlton, R Edward Faught, Ruben I Kuzniecky
(Affiliation: Epilepsy Programme, University of Western Ontario, London Health Science Center, 339 Windermere Road, London, Ontario, Canada. jburneo2 at uwo.ca)
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| Journal | Seizure : the journal of the British Epilepsy Association
(Seizure)
Vol. 17
Issue 4
Pg. 314-9
(Jun 2008)
ISSN: 1059-1311 England |
| PMID | 18024095
(Publication Type: Journal Article)
|
| Topics |
- Adult
- Age of Onset
- Epilepsy, Temporal Lobe
(pathology, surgery)
- Ethnic Groups
- Female
- Functional Laterality
(physiology)
- Hippocampus
(pathology)
- Humans
- Logistic Models
- Magnetic Resonance Imaging
- Male
- Seizures
(epidemiology, surgery)
- Sex Factors
- Survival Analysis
- Temporal Lobe
(surgery)
- Treatment Outcome
|
