| Abstract | BACKGROUND: Left ventricular assist device (LVAD) implantation has proven effective as a bridge to transplantation in end-stage heart failure patients (ESHFPs), although survival during device support is critical. Oxidative stress has been implicated in the development of heart failure, but the influence of redox state on in-hospital post-LVAD outcome has not been clarified. METHODS AND RESULTS: In this report we describe the oxidant/anti-oxidant profiles of 15 ESHFPs before LVAD placement, 5 of whom did not survive to 1 month, and in 30 subjects without cardiac disease, representing the control group. CONCLUSIONS: Preliminary findings suggest that adequate activity of the GPx-1-based anti-oxidant system before device placement is associated with patient survival up to 1 month, despite comparable baseline oxidative stress in patients who both survived and died (within 2 weeks post-LVAD). |
| Authors | Raffaele Caruso, Andrea Garatti, Valentina Sedda, Filippo Milazzo, Jonica Campolo, Tiziano Colombo, Emanuele Catena, Giuliana Cighetti, Claudio Russo, Maria Frigerio, Ettore Vitali, Oberdan Parodi
(Affiliation: CNR Clinical Physiology Institute of Milan, Milan, Italy.)
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| Journal | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
(J Heart Lung Transplant)
Vol. 26
Issue 11
Pg. 1177-81
(Nov 2007)
ISSN: 1557-3117 United States |
| PMID | 18022085
(Publication Type: Journal Article)
|
| Chemical References |
- Biological Markers
- Malondialdehyde
- Glutathione
- GPX3 protein, human
- glutathione peroxidase GPX1
- Glutathione Peroxidase
- Glutathione Reductase
|
| Topics |
- Adult
- Aged
- Biological Markers
(blood)
- Case-Control Studies
- Female
- Glutathione
(blood)
- Glutathione Peroxidase
(blood)
- Glutathione Reductase
(blood)
- Heart Failure
(metabolism, therapy)
- Heart Ventricles
(physiopathology)
- Heart-Assist Devices
- Humans
- Male
- Malondialdehyde
(blood)
- Middle Aged
- Oxidation-Reduction
- Oxidative Stress
(physiology)
- Predictive Value of Tests
- Survival Analysis
- Treatment Outcome
|
