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Coenzyme Q10 (ubiquinol-10) supplementation improves oxidative imbalance in children with trisomy 21.

Abstract
Endogenous coenzyme Q10 is an essential cofactor in the mitochondrial respiratory chain, a potent antioxidant, and a potential biomarker for systemic oxidative status. Evidence of oxidative stress was reported in individuals with trisomy 21. In this study, 14 children with trisomy 21 had significantly increased (P < 0.0001) plasma ubiquinone-10 (the oxidized component of coenzyme Q10) compared with 12 age- and sex-matched healthy children (historical controls). Also, the mean ratio of ubiquinol-10 (the biochemically reduced component):total coenzyme Q10 was significantly decreased (P < 0.0001). After 3 months of ubiquinol-10 supplementation (10 mg/kg/day) to 10 patients with trisomy 21, the mean ubiquinol-10:total coenzyme Q10 ratio increased significantly (P < 0.0001) above baseline values, and 80% of individual ratios were within normal range. No significant or unexpected adverse effects were reported by participants. To our knowledge, this is the first study to indicate that the pro-oxidant state in plasma of children with trisomy 21, as assessed by ubiquinol-10:total coenzyme Q10 ratio, may be normalized with ubiquinol-10 supplementation. Further studies are needed to determine whether correction of this oxidant imbalance improves clinical outcomes of children with trisomy 21.
AuthorsMichael V Miles, Bonnie J Patterson, Melinda L Chalfonte-Evans, Paul S Horn, Francis J Hickey, Mark B Schapiro, Paul E Steele, Peter H Tang, Stephanie L Hotze
JournalPediatric neurology (Pediatr Neurol) Vol. 37 Issue 6 Pg. 398-403 (Dec 2007) ISSN: 0887-8994 [Print] United States
PMID18021919 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Coenzymes
  • Vitamins
  • Ubiquinone
  • coenzyme Q10
Topics
  • Adolescent
  • Case-Control Studies
  • Child
  • Coenzymes (blood, therapeutic use)
  • Down Syndrome (diet therapy, physiopathology)
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Oxidation-Reduction (drug effects)
  • Statistics, Nonparametric
  • Ubiquinone (analogs & derivatives, blood, therapeutic use)
  • Vitamins (blood, therapeutic use)

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