Abstract |
Endogenous coenzyme Q10 is an essential cofactor in the mitochondrial respiratory chain, a potent antioxidant, and a potential biomarker for systemic oxidative status. Evidence of oxidative stress was reported in individuals with trisomy 21. In this study, 14 children with trisomy 21 had significantly increased (P < 0.0001) plasma ubiquinone-10 (the oxidized component of coenzyme Q10) compared with 12 age- and sex-matched healthy children (historical controls). Also, the mean ratio of ubiquinol-10 (the biochemically reduced component):total coenzyme Q10 was significantly decreased (P < 0.0001). After 3 months of ubiquinol-10 supplementation (10 mg/kg/day) to 10 patients with trisomy 21, the mean ubiquinol-10:total coenzyme Q10 ratio increased significantly (P < 0.0001) above baseline values, and 80% of individual ratios were within normal range. No significant or unexpected adverse effects were reported by participants. To our knowledge, this is the first study to indicate that the pro-oxidant state in plasma of children with trisomy 21, as assessed by ubiquinol-10:total coenzyme Q10 ratio, may be normalized with ubiquinol-10 supplementation. Further studies are needed to determine whether correction of this oxidant imbalance improves clinical outcomes of children with trisomy 21.
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Authors | Michael V Miles, Bonnie J Patterson, Melinda L Chalfonte-Evans, Paul S Horn, Francis J Hickey, Mark B Schapiro, Paul E Steele, Peter H Tang, Stephanie L Hotze |
Journal | Pediatric neurology
(Pediatr Neurol)
Vol. 37
Issue 6
Pg. 398-403
(Dec 2007)
ISSN: 0887-8994 [Print] United States |
PMID | 18021919
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Coenzymes
- Vitamins
- Ubiquinone
- coenzyme Q10
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Topics |
- Adolescent
- Case-Control Studies
- Child
- Coenzymes
(blood, therapeutic use)
- Down Syndrome
(diet therapy, physiopathology)
- Female
- Follow-Up Studies
- Humans
- Male
- Oxidation-Reduction
(drug effects)
- Statistics, Nonparametric
- Ubiquinone
(analogs & derivatives, blood, therapeutic use)
- Vitamins
(blood, therapeutic use)
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