| Abstract | Tardive oculogyric crisis (OGC) is a dystonic syndrome that starts after long-term use of dopamine receptor antagonists. Atypical antipsychotics have reduced liability for inducing tardive dystonia and show antidystonic properties in patients with pre-existing tardive dystonia. Clozapine is an atypical antipsychotic drug, and there have been case reports that clozapine may be an effective treatment for tardive dystonia. Surprisingly, we found that three patients appeared to develop tardive OGC while taking clozapine. The relationship between tardive OGC and clozapine is still unknown. However, it is possible that the previous antipsychotic exposure could have created a sensitising or priming effect on the striatum. Also, there are some suggestions of an underlying susceptibility and possibly a genetic predisposition, at least in some patients. |
| Authors | Ozcan Uzun, Ali Doruk
(Affiliation: Department of Psychiatry, Gulhane School of Medicine, Ankara, Turkey. ouzun at gata.edu.tr)
|
| Journal | Clinical drug investigation
(Clin Drug Investig)
Vol. 27
Issue 12
Pg. 861-4
( 2007)
ISSN: 1173-2563 New Zealand |
| PMID | 18020545
(Publication Type: Case Reports, Journal Article)
|
| Chemical References |
- Antipsychotic Agents
- Clozapine
|
| Topics |
- Adult
- Antipsychotic Agents
(adverse effects)
- Clozapine
(adverse effects)
- Dyskinesia, Drug-Induced
(etiology)
- Female
- Genetic Predisposition to Disease
- Humans
- Middle Aged
- Ocular Motility Disorders
(chemically induced)
- Schizophrenia
(drug therapy)
|
