| Abstract | In acute experimental intoxication with 3 indigenous pesticides (Tripinacloraz, Lemax and Maleic Hydrazide-Na salt) the changes of some biochemical parameters, reflecting the degree of hepatic structural alterations, were studied. The pesticides were administered by gastric gavage in a single dose close to DL50 to Wistar male rats. The morphological alterations were in good correlation with a different hepatocellular levels localization. Reversible morphological lesions (granulovascuolar like dystrophy and circulatory disorders) without any pathological significance on dose-effect correlation induced a progressive response especially on serum ceruloplasmine, leucinaminopeptidase and lactatdehydrogenase. |
| Authors | G Filipescu, E Codorean, D Laky, C Tănase, L Ciotaru
(Affiliation: Victor Babeş Institute, Department of Pathology, Bucharest, Romania.)
|
| Journal | Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
(Rom J Morphol Embryol)
1991 Jan-Jun
Vol. 37
Issue 1-2
Pg. 49-54
ISSN: 1220-0522 ROMANIA |
| PMID | 1801979
(Publication Type: Journal Article)
|
| Chemical References |
- Pesticides
- Phthalimides
- Triazoles
- Maleic Hydrazide
- triadimefon
- Lemax
|
| Topics |
- Animals
- Liver
(enzymology, pathology)
- Liver Diseases
(chemically induced, enzymology, pathology)
- Male
- Maleic Hydrazide
(toxicity)
- Pesticides
(toxicity)
- Phthalimides
(toxicity)
- Rats
- Rats, Inbred Strains
- Triazoles
(toxicity)
|
