HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Brief report: stroke in multiple myeloma patient treated with thalidomide].

Abstract
We presented a patient suffered from stroke related to thalidomide therapy. The patient was a 74-year-old man who had about two-year history of multiple myeloma and treated with 100 mg of oral thalidomide daily. He was diagnosed as having cryptogenic stroke attributable to patent foramen ovale, when he admitted to our hospital with sudden onset left-side hemiparesis. Antiplatelet and neuroprotective therapies were commenced along with the use of elastic stocking to prevent further embolic event. Then, warfarin was selected as secondary prevention to reduce the risk of paradoxical embolism during thalidomide therapy. Although the risk of deep vein thrombosis on thalidomide therapy has been well documented, only a few cases have been noted documenting the risk of stroke during thalidomide therapy. We need to be careful about the risk of deep vein thrombosis on thalidomide therapy, even as monotherapy, and consider using anticoagulant therapy while prescribing thalidomide.
AuthorsYasuyuki Ito, Akira Mori, Kiminobu Yonemura, Yoichiro Hashimoto, Teruyuki Hirano, Makoto Uchino
JournalRinsho shinkeigaku = Clinical neurology (Rinsho Shinkeigaku) Vol. 47 Issue 9 Pg. 593-6 (Sep 2007) ISSN: 0009-918X [Print] Japan
PMID18018619 (Publication Type: Case Reports, English Abstract, Journal Article, Review)
Chemical References
  • Anticoagulants
  • Neuroprotective Agents
  • Thalidomide
  • Warfarin
  • Aspirin
Topics
  • Aged
  • Anticoagulants (administration & dosage)
  • Aspirin (administration & dosage)
  • Embolism, Paradoxical (prevention & control)
  • Foramen Ovale, Patent (chemically induced)
  • Humans
  • Male
  • Multiple Myeloma (drug therapy)
  • Neuroprotective Agents (administration & dosage)
  • Risk
  • Stockings, Compression
  • Stroke (chemically induced, prevention & control)
  • Thalidomide (adverse effects)
  • Venous Thrombosis (prevention & control)
  • Warfarin (administration & dosage)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: