| Abstract | 6-(18)F-Fluorodopamine ((18)F-FDA) PET is a highly sensitive tool for the localization of pheochromocytoma (PHEO). The aim of this study was to establish cutoff values for pathologic and physiologic adrenal gland tracer uptake. METHODS: (18)F-FDA PET with CT coregistration was performed in 14 patients (10 men and 4 women; age [mean +/- SD], 42.9 +/- 13.3 y) with unilateral adrenal gland PHEO and in 13 control subjects (5 men and 8 women; age, 51.7 +/- 12.5 y) without PHEO. Standardized uptake values (SUVs) were compared between adrenal glands with PHEO and normal left adrenal glands in control subjects. RESULTS: (18)F-FDA accumulation was observed in all adrenal glands with PHEO and in 6 of 13 control adrenal glands (P = 0.02). The SUV was higher in adrenal glands with PHEO (mean +/- SD, 16.1 +/- 6.1) than in (18)F-FDA-positive control adrenal glands (7.7 +/- 1.4) (P = 0.005). SUV cutoffs for distinguishing between adrenal glands with PHEO and normal adrenal glands were 7.3 (100% sensitivity) and 10.1 (100% specificity). CONCLUSION: The SUVs of adrenal foci on (18)F-FDA PET facilitate the distinction between adrenal glands with PHEO and normal adrenal glands. |
| Authors | Henri J L M Timmers, Jorge A Carrasquillo, Millie Whatley, Graeme Eisenhofer, Clara C Chen, Alexander Ling, W Marston Linehan, Peter A Pinto, Karen T Adams, Karel Pacak
(Affiliation: Reproductive and Adult Endocrinology Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1109, USA.)
|
| Journal | Journal of nuclear medicine : official publication, Society of Nuclear Medicine
(J Nucl Med)
Vol. 48
Issue 12
Pg. 1940-4
(Dec 2007)
ISSN: 0161-5505 United States |
| PMID | 18006611
(Publication Type: Journal Article, Research Support, N.I.H., Intramural)
|
| Chemical References |
- Radiopharmaceuticals
- Fluorodeoxyglucose F18
|
| Topics |
- Adolescent
- Adrenal Gland Neoplasms
(radionuclide imaging)
- Adrenal Glands
(radionuclide imaging)
- Adult
- Aged
- Female
- Fluorodeoxyglucose F18
(diagnostic use)
- Humans
- Male
- Middle Aged
- Pheochromocytoma
(radionuclide imaging)
- Positron-Emission Tomography
(methods)
- Radiopharmaceuticals
(diagnostic use)
|
