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Inhibition of tumor-promoter-enhanced 3H-choline incorporation into cellular phospholipids by phloroglucinol derivatives from Mallotus japonicus.

Abstract
The MeOH and CHCl3 extracts of the pericarps of Mallotus japonicus showed potential anti-tumor-promoter activity. Seven constituents of the CHCl3 extract and two derivatives from the most abundant constituent, mallotojaponin, markedly inhibited the incorporation of 3H-choline into phospholipids of C3H101/2 cells enhanced by 12-O-tetradecanoylphorbol-13-acetate (TPA), a potent tumor promoter.
AuthorsM Arisawa, A Fujita, N Morita, T Okuyama, H Nishino
JournalJournal of natural products (J Nat Prod) Vol. 54 Issue 5 Pg. 1409-12 ( 1991) ISSN: 0163-3864 [Print] United States
PMID1800639 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anticarcinogenic Agents
  • Phospholipids
  • Phloroglucinol
  • Choline
Topics
  • Anticarcinogenic Agents (chemistry, isolation & purification, pharmacology)
  • Cell Line
  • Choline (metabolism)
  • Phloroglucinol (analogs & derivatives, isolation & purification, pharmacology)
  • Phospholipids (metabolism)

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