Abstract |
The absolute stereo structure of the natural product laurenditerpenol (1S, 6R, 7S, 10R, 11R, 14S, 15R) has been accomplished from eight plausible stereoisomers by its first asymmetric total synthesis in a highly convergent and flexible synthetic pathway. Six stereoisomers of laurenditerpenol were synthesized and evaluated for their biological activity.
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Authors | Amar G Chittiboyina, Gundluru Mahesh Kumar, Paulo B Carvalho, Yang Liu, Yu-Dong Zhou, Dale G Nagle, Mitchell A Avery |
Journal | Journal of medicinal chemistry
(J Med Chem)
Vol. 50
Issue 25
Pg. 6299-302
(Dec 13 2007)
ISSN: 0022-2623 [Print] United States |
PMID | 18004798
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Diterpenes
- Hypoxia-Inducible Factor 1
- laurenditerpenol
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Topics |
- Cell Hypoxia
- Cell Line, Tumor
- Diterpenes
(chemical synthesis, chemistry, pharmacology)
- Humans
- Hypoxia-Inducible Factor 1
(antagonists & inhibitors, biosynthesis)
- Molecular Conformation
- Stereoisomerism
- Structure-Activity Relationship
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