Abstract | PURPOSE: MATERIALS AND METHODS: RESULTS: The change in the total score of O'Leary-Sant Interstitial Cystitis Symptoms/Problems Index from baseline to week 12 among the treatment group (median -12 or approximately a 46% reduction) was significantly greater compared to the placebo group (median -5.5 or approximately a 24% reduction, p = 0.04). At week 18 the treatment group showed statistically significant improvement in all Health Related Quality of Life domains compared to the baseline (p < or = 0.01), while the placebo group showed significant improvement in only 3 Health Related Quality of Life domains, (p < or = 0.05) compared to the baseline. There were no significant differences within major categories of adverse events between treated and placebo groups. CONCLUSIONS:
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Authors | Edward L Davis, Samar R El Khoudary, Evelyn O Talbott, Josephine Davis, Lisa J Regan |
Journal | The Journal of urology
(J Urol)
Vol. 179
Issue 1
Pg. 177-85
(Jan 2008)
ISSN: 1527-3792 [Electronic] United States |
PMID | 18001798
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Pentosan Sulfuric Polyester
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Topics |
- Administration, Intravesical
- Administration, Oral
- Adult
- Aged
- Cystitis, Interstitial
(drug therapy)
- Double-Blind Method
- Female
- Humans
- Middle Aged
- Pentosan Sulfuric Polyester
(administration & dosage, adverse effects)
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