| Abstract | The effects of carbamazepine and valproic acid on disturbances of behaviour, elimination of ethanol, acetaldehyde from the blood, the contents of adrenaline, noradrenaline, dopamine, serotonin, 5-hydroxyindoleacetic acid and histamine in the brain and blood in alcoholic postintoxication syndrome were studied on male albino rats. Carbamazepine and valproic acid were shown to reduce the behavioural manifestations of the syndrome, to increase elimination of ethanol and acetaldehyde, to normalize the levels of the mediators in the brain tissues, particularly in the thalamus. |
| Authors | L V Mitina, A L Khokhlov |
| Journal | Farmakologiia i toksikologiia
(Farmakol Toksikol)
1991 Sep-Oct
Vol. 54
Issue 5
Pg. 60-2
ISSN: 0014-8318 USSR |
| Vernacular Title | Otsenka éffektivnosti karbamazepina i val'proevoĭ kisloty pri alkogol'nom postintoksikatsionnom sindrome po kinetike étanola i atsetal'degida i soderzhaniiu biogennykh monoaminov. |
| PMID | 1800156
(Publication Type: Comparative Study, English Abstract, Journal Article)
|
| Chemical References |
- Biogenic Monoamines
- Carbamazepine
- Diazepam
- Ethanol
- Acetaldehyde
- Valproic Acid
|
| Topics |
- Acetaldehyde
(pharmacokinetics)
- Alcoholic Intoxication
(drug therapy, metabolism)
- Animals
- Biogenic Monoamines
(metabolism)
- Brain
(drug effects, metabolism)
- Carbamazepine
(therapeutic use)
- Diazepam
(therapeutic use)
- Drug Evaluation, Preclinical
- Ethanol
(pharmacokinetics)
- Male
- Rats
- Syndrome
- Time Factors
- Valproic Acid
(therapeutic use)
|
