Cystoid and diabetic macular edema treated with nepafenac 0.1%.

Abstract

Cystoid macular edema (CME), a common complication following cataract surgery, is routinely medically treated with topical nonsteroidal anti-inflammatory drugs (NSAIDs), alone or in combination with steroids. In this paper, we describe 6 patients with CME and 1 patient with diabetic macular edema (DME), all of whom were treated with nepafenac 0.1%, a novel prodrug NSAID. Three (3) patients with acute CME following cataract surgery were treated for 3-4 weeks with nepafenac 0.1%, with or without concomitant steroids. Both retinal thickness and visual acuity improved in all 3 cases. The 3 patients with chronic CME, each of whom had been previously treated with steroids with or without concomitant NSAID therapy, were started on nepafenac 0.1% three times daily. Retinal thickness and visual acuity improved in each case, except for 1 patient with 20/25 pretreatment visual acuity. The mean improvement in visual acuity of all 6 CME patients was 2.5 lines and the mean decrease in retinal thickness was 282.8 microm. The patient with DME also showed improvement in retinal thickness and visual acuity after 6 months of treatment with nepafenac. These clinical data strongly suggest that nepafenac 0.1% is a promising drug for the treatment of posterior segment inflammation, including CME, and warrants further investigation.

• Authors: Seenu M Hariprasad, David Callanan, Steven Gainey, Yu-Guang He, Keith Warren
• Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics (J Ocul Pharmacol Ther) Vol. 23 Issue 6 Pg. 585-90 (Dec 2007) ISSN: 1080-7683 [Print] United States
• PMID: 18001248 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Benzeneacetamides
• Phenylacetates
• Steroids
• nepafenac

Topics

• Aged
• Benzeneacetamides (therapeutic use)
• Cataract Extraction (adverse effects)
• Diabetic Retinopathy (diagnosis, drug therapy, surgery)
• Female
• Humans
• Lenses, Intraocular (adverse effects)
• Macular Edema (diagnosis, drug therapy, surgery)
• Male
• Phenylacetates (therapeutic use)
• Steroids (therapeutic use)
• Tomography, Optical Coherence (methods)
• Treatment Outcome
• Visual Acuity (drug effects)