Comparison of the effects of latanoprost and bimatoprost on intraocular pressure in chronic angle-closure glaucoma.

Abstract

PURPOSE:

The aim of this study was to compare the intraocular pressure (IOP)-lowering effect of latanoprost and bimatoprost as primary therapy in patients with chronic angle-closure glaucoma (CACG) after peripheral iridotomy.

METHODS:

Eighty-two (82) consecutive CACG patients with an IOP greater than 19 mmHg after a peripheral iridotomy were recruited. CACG was defined as chronic elevated IOP, glaucomatous optic neuropathy, and a corresponding visual field defect in eyes with occludable angle and peripheral anterior synechiae on gonioscopy. Patients were randomly assigned to two groups based on daily treatment with either latanoprost 0.005% or bimatoprost 0.03% in the evening for 12 weeks. The IOP was measured at 9 AM and 4 PM on the same day at baseline and also at 4, 8, and 12 weeks. Between-group differences in mean diurnal IOP and IOP reduction were analyzed.

RESULTS:

After 12 weeks of treatment, mean IOP for both the latanoprost and bimatoprost groups was significantly reduced when compared to the baseline value (21.6 +/- 1.9 to 16.4 +/- 2.5 mmHg and 22.1 +/- 2.0 to 16.9 +/- 2.4 mmHg, respectively; P < 0.001 for both). There was no significant difference in IOP reduction between the two treatment groups (P = 0.40). At 4 and 8 weeks, the IOP changes from baseline were statistically significant at both times for both drugs (all P < 0.001).

CONCLUSIONS:

Both latanoprost and bimatoprost significantly reduced IOP in CACG patients who were inadequately treated by laser peripheral iridotomy.

• Authors: Mei-Ju Chen, Yen-Cheng Chen, Ching-Kuang Chou, Wen-Ming Hsu
• Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics (J Ocul Pharmacol Ther) Vol. 23 Issue 6 Pg. 559-66 (Dec 2007) ISSN: 1080-7683 [Print] United States
• PMID: 18001247 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Amides
• Antihypertensive Agents
• Lipids
• Prostaglandins F, Synthetic
• Cloprostenol
• Latanoprost
• Bimatoprost

Topics

• Aged
• Aged, 80 and over
• Amides (administration & dosage, therapeutic use)
• Antihypertensive Agents (administration & dosage, therapeutic use)
• Bimatoprost
• Chronic Disease
• Cloprostenol (administration & dosage, analogs & derivatives, therapeutic use)
• Female
• Follow-Up Studies
• Glaucoma, Angle-Closure (drug therapy, surgery)
• Humans
• Intraocular Pressure (drug effects)
• Iridectomy
• Laser Therapy
• Latanoprost
• Lipids (administration & dosage, therapeutic use)
• Male
• Middle Aged
• Prospective Studies
• Prostaglandins F, Synthetic (administration & dosage, therapeutic use)
• Treatment Outcome