| Abstract | PURPOSE: The aim of this study was to compare the intraocular pressure (IOP)-lowering effect of latanoprost and bimatoprost as primary therapy in patients with chronic angle-closure glaucoma (CACG) after peripheral iridotomy. METHODS: Eighty-two (82) consecutive CACG patients with an IOP greater than 19 mmHg after a peripheral iridotomy were recruited. CACG was defined as chronic elevated IOP, glaucomatous optic neuropathy, and a corresponding visual field defect in eyes with occludable angle and peripheral anterior synechiae on gonioscopy. Patients were randomly assigned to two groups based on daily treatment with either latanoprost 0.005% or bimatoprost 0.03% in the evening for 12 weeks. The IOP was measured at 9 AM and 4 PM on the same day at baseline and also at 4, 8, and 12 weeks. Between-group differences in mean diurnal IOP and IOP reduction were analyzed. RESULTS: After 12 weeks of treatment, mean IOP for both the latanoprost and bimatoprost groups was significantly reduced when compared to the baseline value (21.6 +/- 1.9 to 16.4 +/- 2.5 mmHg and 22.1 +/- 2.0 to 16.9 +/- 2.4 mmHg, respectively; P < 0.001 for both). There was no significant difference in IOP reduction between the two treatment groups (P = 0.40). At 4 and 8 weeks, the IOP changes from baseline were statistically significant at both times for both drugs (all P < 0.001). CONCLUSIONS: Both latanoprost and bimatoprost significantly reduced IOP in CACG patients who were inadequately treated by laser peripheral iridotomy. |
| Authors | Mei-Ju Chen, Yen-Cheng Chen, Ching-Kuang Chou, Wen-Ming Hsu
(Affiliation: Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China. mj_chen at vghtpe.gov.tw)
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| Journal | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
(J Ocul Pharmacol Ther)
Vol. 23
Issue 6
Pg. 559-66
(Dec 2007)
ISSN: 1080-7683 United States |
| PMID | 18001247
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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| Chemical References |
- Amides
- Antihypertensive Agents
- Lipids
- Prostaglandins F, Synthetic
- bimatoprost
- latanoprost
- Cloprostenol
|
| Topics |
- Aged
- Aged, 80 and over
- Amides
(administration & dosage, therapeutic use)
- Antihypertensive Agents
(administration & dosage, therapeutic use)
- Chronic Disease
- Cloprostenol
(administration & dosage, analogs & derivatives, therapeutic use)
- Female
- Follow-Up Studies
- Glaucoma, Angle-Closure
(drug therapy, surgery)
- Humans
- Intraocular Pressure
(drug effects)
- Iridectomy
- Laser Therapy
- Lipids
(administration & dosage, therapeutic use)
- Male
- Middle Aged
- Prospective Studies
- Prostaglandins F, Synthetic
(administration & dosage, therapeutic use)
- Treatment Outcome
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