| Abstract | To assess the effect of a bolus of terlipressin in brain-dead donors with shock refractory to norepinephrine, a retrospective study was conducted in a 16-bed intensive care unit of a university hospital. Twenty brain-dead donors were treated with norepinephrine within the study period. Nine of these donors developed persisting hypotension (MAP < 65 mmHg) not responding to fluid loading and high dose of norepinephrine. They were then treated with a single bolus of terlipressin (1 mg). This resulted in a MAP rise from 58 +/- 10 to 93 +/- 20 mmHg (P = 0.009). One month after transplantation, no differences were observed in serum creatinine levels of the recipients who received a renal transplant extracted from donors responding or not to norepinephrine (138 +/- 43 vs. 137 +/- 43 microM; P = 0.95). The liver function was similar in both groups. Within the limitations of this study, a single bolus of terlipressin in norepinephrine-resistant vasodilatory shock donors does not affect the renal and liver graft quality in the recipients. |
| Authors | Valéry Blasco, Marc Leone, Alain Geissler, François Antonini, Jacques Albanèse, Claude Martin
(Affiliation: Département d'Anesthésie et de Réanimation, Hôpital Nord, Marseille, France.)
|
| Journal | Shock (Augusta, Ga.)
(Shock)
Vol. 29
Issue 6
Pg. 667-9
(Jun 2008)
ISSN: 1073-2322 United States |
| PMID | 17998885
(Publication Type: Comparative Study, Journal Article)
|
| Chemical References |
- Antihypertensive Agents
- terlipressin
- Lysine Vasopressin
- Norepinephrine
- Creatinine
|
| Topics |
- Adult
- Aged
- Antihypertensive Agents
(administration & dosage)
- Brain Death
(blood, physiopathology)
- Creatinine
(blood)
- Female
- Graft Survival
(drug effects)
- Humans
- Hypotension
(blood, chemically induced)
- Kidney
(metabolism, physiopathology)
- Kidney Transplantation
- Liver
(metabolism, physiopathology)
- Lysine Vasopressin
(administration & dosage, analogs & derivatives)
- Male
- Middle Aged
- Norepinephrine
(administration & dosage, adverse effects)
- Recovery of Function
(drug effects)
- Retrospective Studies
- Shock
(blood, chemically induced)
- Transplantation, Homologous
|
