The activating killer cell immunoglobulin-like receptors as important determinants of acute graft-versus host disease in hematopoietic stem cell transplantation for acute myelogenous leukemia.
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| Abstract | BACKGROUND: We investigated the influence of killer cell immunoglobulin-like receptor (KIR) genes, based on the genotypes of inhibitory or activating KIR, in stem cell recipients with acute myelogenous leukemia and their human leukocyte antigen-matched sibling donors on acute graft-versus host disease (GVHD) after hematopoietic stem cell transplantation. METHODS: We studied 53 consecutive donor-recipient pairs to determine the impact of KIR genotypes and their bidirectional KIR interactions. RESULTS: All activating KIR genes in donors were important factors for determining outcome in a manner distinctive for each gene studied. Specifically, the 2DS2 gene and the 2DS4*003 allele were closely correlated with acute GVHD. The 2DS1 gene was associated with a better long-term survival, even if present only in the donor and not the recipient. The 2DS3-2DS5 dual genes were more often involved in a variety of transplant-related complications. CONCLUSIONS: In conclusion, these factors may help predict transplant outcomes and aid in our understanding of immunogenetic specificity.
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| Authors | Hee-Je Kim, Young Choi, Woo-Sung Min, Tai-Gyu Kim, Byung-Sik Cho, Sung-Yong Kim, Ki-Sung Eom, Seok Lee, Chang-Ki Min, Seok-Goo Cho, Dong-Wook Kim, Jong-Wook Lee, Chun-Choo Kim |
| Journal | Transplantation (Transplantation) Vol. 84 Issue 9 Pg. 1082-91 (Nov 15 2007) ISSN: 0041-1337 [Print] United States |
| PMID | 17998861 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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