Pharmacological preconditioning with hyperbaric oxygen: can this therapy attenuate myocardial ischemic reperfusion injury and induce myocardial protection via nitric oxide?

Ischemic reperfusion injury (IRI) is an inevitable part cardiac surgery such as coronary artery bypass graft (CABG). While ischemic hypoxia and the ensuing normoxic or hyperoxic reperfusion are critical to the initiation and propagation of IRI, conditioning myocardial cells to an oxidative stress prior to IRI may limit the consequences of this injury. Hyperbaric oxygen (HBO2) is a modality of treatment that is known to generate an oxidative stress. Studies have shown that treatment with HBO2 postischemia and reperfusion is useful in ameliorating myocardial IRI. Moreover, preconditioning the myocardium with HBO2 before reperfusion has demonstrated a myocardial protective effect by limiting the infarct size post ischemia and reperfusion. Current evidence suggests that HBO2 preconditioning may partly attenuate IRI by stimulating the endogenous production of nitric oxide (NO). As NO has the capacity to reduce neutrophil sequestration, adhesion and associated injury, and improve vascular flow, HBO2 preconditioning induced NO may play a role in providing myocardial protection during interventions that involve an inevitable episode of IRI. This current opinion review article attempts to suggest that HBO2 may be used to pharmacologically precondition and protect the myocardium from the effects of IRI that is known to occur during cardiac surgery.
AuthorsJeysen Zivan Yogaratnam, Gerard Laden, Lavent Guvendik, Mike Cowen, Alex Cale, Steve Griffin
JournalThe Journal of surgical research (J Surg Res) Vol. 149 Issue 1 Pg. 155-64 (Sep 2008) ISSN: 1095-8673 [Electronic] United States
PMID17996900 (Publication Type: Journal Article, Review)
Chemical References
  • Nitric Oxide
  • Animals
  • Cardiac Surgical Procedures (adverse effects)
  • Humans
  • Hyperbaric Oxygenation
  • Ischemic Preconditioning, Myocardial (methods)
  • Myocardial Reperfusion Injury (etiology, metabolism, therapy)
  • Nitric Oxide (metabolism)
  • Rats

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: