Abstract | OBJECTIVE: METHODS: RESULTS: After one week's treatment, the GSH level in plasma of experiment group and the ratio of GSH and GSSG (GSH/ GSSG) were significantly increased comparing with control group (both P<0.01), while GSSG, MDA and ox-LDL levels significantly lowered comparing with control group(all P<0.01). The premature beats diminished 86.5% in experiment group, but the decrease rate in control group was only 47.4% (P<0.01). The improvement in indexes of oxidative stress status (including GSH/ GSSG, MDA and ox-LDL) and the reduction of premature beats showed close correlation with each other (all P<0.01). No adverse effects of the drug were found after one week of administration of Potassium magnesium aspartate. CONCLUSION:
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Authors | Yan-fang Zhi, Yan-sheng Huang, Bo-shi Xu, Shu-ren Wang |
Journal | Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
(Zhongguo Wei Zhong Bing Ji Jiu Yi Xue)
Vol. 19
Issue 11
Pg. 662-6
(Nov 2007)
ISSN: 1003-0603 [Print] China |
PMID | 17996133
(Publication Type: English Abstract, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cardiotonic Agents
- Lipoproteins, LDL
- oxidized low density lipoprotein
- Malondialdehyde
- Potassium Magnesium Aspartate
- Glutathione
- Glutathione Disulfide
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Angina Pectoris
(blood, drug therapy)
- Arrhythmias, Cardiac
(blood, drug therapy)
- Cardiotonic Agents
(therapeutic use)
- Female
- Glutathione
(blood)
- Glutathione Disulfide
(blood)
- Humans
- Lipid Peroxidation
(drug effects)
- Lipoproteins, LDL
(blood)
- Male
- Malondialdehyde
(blood)
- Middle Aged
- Oxidative Stress
(drug effects)
- Potassium Magnesium Aspartate
(therapeutic use)
- Single-Blind Method
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