HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Determinants of protection against diphtheria in adult hemodialysis patients.

Abstract
Diphtheria is of great epidemiological concern. Although mainly observed during childhood, unvaccinated adults and relatively immunocompromised patients are at increased risk for acquiring diphtheria. We aimed to determine the rates and certain determinants of protection against diphtheria in adult hemodialysis (HD) patients. Protection rates of 322 HD patients were compared with 65 diabetes mellitus type 2 (DM) patients and 65 healthy controls. A questionnaire was held in regard to smoking habits and alcohol intake. Antibody levels against diphtheria were assessed by an in-house ELISA and a concentration of >or=0.1 IU/mL was regarded as protective. Effects of age, gender and time being on dialysis on protection were assessed by logistic regression. Ratios of individuals with protective antibody levels were found to be 36% (116/322), 27.7% (18/65), and 52.3% (34/65) for HD, DM, and control groups, respectively. Hemodialysis patients had a significantly (p < 0.05) lower protection rate than healthy controls. In all study groups, there was a tendency of higher protection rate with increasing age. These low ratios of protected individuals in both HD and DM patient groups are alarming, as these patients generally have defects in vaccine responses, and carriage is important in the perpetuation of diphtheria. The protection status of these patient groups might be improved with additional vaccinations.
AuthorsResul Karakus, Arzu Latife Aral, Derya Ozcan Kanat, Kenan Hizel, Kayhan Caglar, Sukru Sindel, Ilhan Yetkin, Cemalettin Aybay
JournalRenal failure (Ren Fail) Vol. 29 Issue 7 Pg. 829-34 ( 2007) ISSN: 0886-022X [Print] England
PMID17994451 (Publication Type: Journal Article)
Chemical References
  • Antibodies, Bacterial
Topics
  • Adult
  • Aged
  • Antibodies, Bacterial (blood)
  • Corynebacterium diphtheriae (immunology)
  • Diabetes Mellitus (immunology)
  • Diphtheria (prevention & control)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Renal Dialysis (adverse effects)
  • Surveys and Questionnaires

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: