[Effect of Bnxia Xexin Decoction and its disassembled recipes on somatostatin in rats with stress gastric ulcer].

Abstract

OBJECTIVE:

To explore the acting mechanism of Banxia Xiexin Decoction (BXD) and its disassembled recipes on stress gastric ulcer, for providing references to the scientific researches on the assembling rule of BXD.

METHODS:

The rat model of acute gastric ulcer was established by water immersion-restraint stress. The experimental rats were divided into the normal group, the model group and the treated groups treated with BXD and its disassembled recipes respectively to observe the therapeutic efficacy and the changes of somatostatin (SS) expression in brain and gastric tissues.

RESULTS:

In the model group, the SS expression was 0.0237 +/- 0.0056 in brain and 0.0171 +/- 0.0053 in gastric tissue respectively, which was significantly lower than those in the normal group (0.0305 +/- 0.0024 and 0.0282 +/- 0.0037) respectively. Compared to the model group, the two indexes in rats treated with full BXD were 0.0294 +/- 0.0050 and 0.0288 +/- 0.0027, treated with sweet flavor portion were 0.0314 +/- 0.0027 and 0.0219 +/- 0.0059, all showed increase of SS expression, and the increment was more significant in the former.

CONCLUSION:

BXD can increase the expression of SS to realize its therapeutic efficacy, and the recipe was assembled rationally.

• Authors: Zhong Zhang, Yin-chu Si, Li-min Bai
• Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (Zhongguo Zhong Xi Yi Jie He Za Zhi) Vol. 27 Issue 10 Pg. 916-8 (Oct 2007) ISSN: 1003-5370 [Print] China
• PMID: 17990461 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Ulcer Agents
• Plant Extracts
• banxiaxiexintang decoction
• Somatostatin

Topics

• Animals
• Anti-Ulcer Agents (therapeutic use)
• Immunohistochemistry
• Male
• Phytotherapy
• Plant Extracts (chemistry, therapeutic use)
• Random Allocation
• Rats
• Rats, Wistar
• Somatostatin (biosynthesis)
• Stomach Ulcer (drug therapy, etiology, metabolism)
• Stress, Psychological (complications)