[Therapeutic outcome in tibial pseudarthrosis: bone morphogenetic protein 7 (BMP-7) versus autologous bone grafting for tibial fractures].

Abstract

Depending on the type and localisation, nonunions of tibial fractures will occur in 10-40% of cases. Bone morphogenetic protein 7 (BMP-7; Osigraft), a recombinant bone growth factor, can be implanted locally as an alternative to autologous bone grafting. The objective of our study was to compare the efficiency of the two procedures. From January 1995 to December 2002, 82 patients (group 1) with delayed union of a tibial fracture received autologous bone grafting as their first procedure. To compare their results with the efficiency of BMP-7, between May 2002 and June 2005 we followed up on 26 patients (group 2) who had local implantation of BMP-7 after having had, on average, four surgical procedures. Healing was considered successful if x-rays showed bony consolidation and if no further procedure was necessary. Group 1 had no signs of consolidation in 24 cases (28%), whereas group 2 had only two (8%) such patients (p=0.025). The BMP-7 group showed a significantly higher success rate compared with patients with autologous bone grafting, despite the fact that the BMP-7 group contained more complicated cases.

• Authors: G Zimmermann, U Müller, C Löffler, A Wentzensen, A Moghaddam
• Journal: Der Unfallchirurg (Unfallchirurg) Vol. 110 Issue 11 Pg. 931-8 (Nov 2007) ISSN: 0177-5537 [Print] Germany
• Vernacular Title: Therapieerfolg bei atrophen Tibiaschaftpseudarthrosen : Bone Morphogenetic Protein 7 (BMP 7) versus autologe Spongiosaplastik.
• PMID: 17989951 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Bone Morphogenetic Proteins
• osteogenic protein 1 putty, recombinant human

Topics

• Adult
• Bone Morphogenetic Proteins (therapeutic use)
• Bone Transplantation
• Female
• Follow-Up Studies
• Fracture Fixation, Internal
• Fracture Healing (drug effects)
• Humans
• Male
• Middle Aged
• Pseudarthrosis (diagnostic imaging, surgery)
• Radiography
• Reoperation
• Retrospective Studies
• Tibial Fractures (diagnostic imaging, surgery)