| Abstract | Degeneration of the dopaminergic system in Parkinson's disease and longstanding exposure to dopaminergic drugs may cause reward system malfunction. This may manifest as addiction to l-dopa and behavioral disturbances associated with the impulse control system. These disturbances include: gambling, excessive spending (shopping), hypersexuality and binge eating. We included one such patient's personal story to emphasize the devastating consequences of these potentially reversible phenomena: the patient describes in his own words how gambling induced by an exposure dopamine agonist therapy significantly worsened his disease-related difficulties. |
| Authors | Doron Merims, Nir Giladi
(Affiliation: Movement Disorders Unit, Department of Neurology, Tel-Aviv Sourasky Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.)
|
| Journal | Parkinsonism & related disorders
(Parkinsonism Relat Disord)
Vol. 14
Issue 4
Pg. 273-80
( 2008)
ISSN: 1353-8020 England |
| PMID | 17988927
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
|
| Chemical References |
- Antiparkinson Agents
- Levodopa
- Dopamine
|
| Topics |
- Antiparkinson Agents
(adverse effects)
- Behavioral Symptoms
(etiology)
- Dopamine
(metabolism)
- Gambling
- Humans
- Levodopa
(adverse effects)
- Parkinson Disease
(complications, drug therapy, psychology)
- Substance-Related Disorders
(etiology)
|
