Abstract | OBJECTIVE: DESIGN: This multicenter, parallel group, randomized controlled trial involved 363 prevalent CAPD patients from 8 centers. The primary endpoint was peritonitis rate; secondary endpoints were technique failure and technical problems encountered. The duration of the evaluation was 1 year. RESULTS: The risk of peritonitis on Carex varied between the centers. We found a significant treatment-center interaction effect (likelihood ratio test: p = 0.03). The incidence rate ratio ( IRR) of peritonitis on Carex as compared with Ultra ranged from 0.4 to 7.2. In two centers, Carex was inferior to Ultra with regard to peritonitis; but, in five centers, the results were inconclusive. Equivalence was not demonstrated in any center. The overall rate of peritonitis in the Carex group was twice that in the Ultra group [ IRR: 2.18; 95% confidence interval (CI): 1.51 to 3.14]. Technique failure and technical problems were more common with the Carex system. Technique failure rate at 1 year was 44% in the Carex group and 22% in the Ultra group. CONCLUSIONS: Equivalence between the Carex disconnect system and the Ultra disconnect system could not be demonstrated. The risk of peritonitis on Carex varied significantly between centers.
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Authors | Loke-Meng Ong, Teck-Onn Lim, Lai-Seong Hooi, Zaki Morad, Poh-Choo Tan, Hin-Seng Wong, Yam-Ngo Lim, Rozina Ghazalli, Chwee-Choon Tan, Wan Shaariah, Boon-Seng Liew |
Journal | Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis
(Perit Dial Int)
Vol. 23 Suppl 2
Pg. S139-43
(Dec 2003)
ISSN: 1718-4304 [Electronic] United States |
PMID | 17986534
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Child
- Female
- Humans
- Male
- Middle Aged
- Peritoneal Dialysis, Continuous Ambulatory
(instrumentation)
- Peritonitis
(epidemiology)
- Young Adult
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