Abstract | BACKGROUND AND OBJECTIVES: METHODS: From February 2005 to November 2006, all patients with grade 4 erosive reflux esophagitis were screened for the study. Eligible patients were randomized into two groups. Each patient in the study group received intravenous pantoprazole 80 mg loading dose over 5 min, followed by 8 mg/h intravenous infusion for 72 h, then 40 mg orally once a day for 4 days. Each patient in the control group received 40 mg pantoprazole intravenously once a day for 72 h, then orally once a day for 4 days. A second endoscopic gastrointestinal examination (EGD) was performed on treatment days 6-8 (+/-1 day if day 7 was on a weekend) to document any healing of esophagitis in either the study or the control group. RESULTS: In the study group, severe erosive esophagitis healed completely in three patients and significantly in the other three by the time of the second endoscopy. In the control group, severe erosive esophagitis healed partially in five patients, and no improvement was seen at all in one patient by the time of second endoscopy. The difference in the intervention between those two groups was statistically different (P = 0.015). There were no significant complications in either group. CONCLUSIONS: Severe erosive esophagitis can be completely healed in a few days if pantoprazole is given intravenously and continuously for 72 h. It is safe to give pantoprazole intravenously and continuously for treatment of severe erosive esophagitis.
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Authors | Qiang Cai, Mahmoud Barrie, Henry Olejeme, Marc D Rosenberg |
Journal | Digestive diseases and sciences
(Dig Dis Sci)
Vol. 53
Issue 6
Pg. 1500-5
(Jun 2008)
ISSN: 0163-2116 [Print] United States |
PMID | 17985242
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- 2-Pyridinylmethylsulfinylbenzimidazoles
- Anti-Ulcer Agents
- Pantoprazole
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Topics |
- 2-Pyridinylmethylsulfinylbenzimidazoles
(administration & dosage, therapeutic use)
- Anti-Ulcer Agents
(administration & dosage, therapeutic use)
- Esophagitis, Peptic
(drug therapy)
- Female
- Humans
- Infusions, Intravenous
- Male
- Middle Aged
- Pantoprazole
- Pilot Projects
- Time Factors
- Treatment Outcome
- Wound Healing
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