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[Magnesium hydroxide and aluminum hydroxide in the treatment of gastroesophageal reflux].

Abstract
Fifteen children with gastro-esophageal reflux took part in a treatment trial with a regimen of magnesium hydroxide and aluminium hydroxide for 8 weeks period (700 mmol/1.73 mq/die). All children were evaluated clinically and underwent a 24-hour continuous esophageal pH-monitoring both at diagnosis and after 8 weeks of treatment. After therapy 12/15 children were cured and 3/15 improved. Moreover the total percentage of time during which pH was less than 4, the number of reflux episodes and the number of refluxes lasting than 5' recorded during 24-hour continuous esophageal pH-monitoring were significantly reduced after treatment. The Authors conclude that antacids in large quantities are effective in medical treatment of gastro-esophageal reflux.
AuthorsG Iacono, A Carroccio, G Montalto, F Cavataio, S Ippolito, I Kazmierska, V Balsamo
JournalMinerva pediatrica (Minerva Pediatr) Vol. 43 Issue 12 Pg. 797-800 (Dec 1991) ISSN: 0026-4946 [Print] Italy
Vernacular TitleIdrossido di magnesio e idrossido di alluminio nel trattamento del reflusso gastro-esofageo.
PMID1798406 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article)
Chemical References
  • Antacids
  • Drug Combinations
  • aluminum hydroxide, magnesium hydroxide, drug combination
  • Aluminum Hydroxide
  • Magnesium Hydroxide
Topics
  • Aluminum Hydroxide (therapeutic use)
  • Antacids (therapeutic use)
  • Child
  • Child, Preschool
  • Drug Combinations
  • Female
  • Gastroesophageal Reflux (diagnosis, drug therapy)
  • Humans
  • Hydrogen-Ion Concentration
  • Infant
  • Magnesium Hydroxide (therapeutic use)
  • Male
  • Monitoring, Physiologic
  • Time Factors

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