Frequency of HLA-B27 alleles in Brazilian patients with psoriatic arthritis.

Abstract

This prospective study analyzed the frequency of HLA-B27 and its alleles in 102 Brazilian patients with psoriatic arthritis (PsA). The association of the HLA-B27 alleles with these variants was compared to a control healthy HLA-B27 positive group of 111 individuals. There was a predominance of male gender (59.8%), Caucasian race (89.2%), and negative HLA-B27 (79.4%) patients. Asymmetric oligoarthritis (62.7%) was the most frequently observed clinical PsA subgroup, followed by spondylitis (16.7%), and polyarthritis (15.7%). Male gender and the spondylitis subgroup were statistically associated to the positive HLA-B27, and the oligoarthritis subgroup was associated to the negative HLA-B27. Among the 21 HLA-B27-positive PsA patients, there was a significant prevalence of the HLA-B*2705 allele (90.5%), similar to that observed in the control group (80.2%); HLA-B*2703 and HLA-B*2707 were statistically associated to the control group.

• Authors: Rubens Bonfiglioli, Roseneide A Conde, Percival D Sampaio-Barros, Paulo Louzada-Junior, Eduardo A Donadi, Manoel B Bertolo
• Journal: Clinical rheumatology (Clin Rheumatol) Vol. 27 Issue 6 Pg. 709-12 (Jun 2008) ISSN: 0770-3198 [Print] Germany
• PMID: 17982707 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• HLA-B27 Antigen

Topics

• Adult
• Alleles
• Arthritis, Psoriatic (ethnology, genetics)
• Black People (statistics & numerical data)
• Brazil (epidemiology)
• Female
• Genetic Predisposition to Disease (ethnology)
• HLA-B27 Antigen (genetics)
• Humans
• Male
• Middle Aged
• Prevalence
• Prospective Studies
• White People (statistics & numerical data)