Abstract | BACKGROUND: METHODS: Fourteen pigs were anaesthetized and their lungs mechanically ventilated. Sepsis was induced with i.v. infusion of live Pseudomonas aeruginosa [1x10(8) colony forming units (CFU) ml(-1) kg(-1)] for 1 h. Sixty minutes later, the animals received in a random succession either SNP or normal saline for 30 min. Mean arterial pressure (MAP), cardiac index (CI), mean pulmonary artery pressure (MPAP), carbon dioxide tension of the ileal mucosa (PCO2; by gas tonometry), ileal mucosal and hepatic MBF by laser Doppler flowmetry, blood gases, and lactates were assessed before, during administration, and 30 min after discontinuing the test drug. RESULTS: Bacterial infusion promoted hypodynamic shock (MAP -18%, CI -33%, ileal MBF -19%, and hepatic MBF -27%), which was converted to normodynamic shock by resuscitation. During SNP infusion, ileal mucosal MBF significantly increased (+19%) compared with control (P = 0.033). Although hepatic MBF increased (+42% from baseline), this did not differ from control. In order to maintain a constant central venous pressure and MAP, fluid loading and norepinephrine (P < 0.01) were increased. Acid-base status was not altered by SNP. CONCLUSIONS: In a resuscitated porcine model of the early phase of septic shock, SNP improved ileal mucosal MBF but required a concomitant increase in fluid and norepinephrine supplements to maintain constant systemic haemodynamic parameters.
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Authors | A Assadi, O Desebbe, C Kaminski, T Rimmelé, F Bénatir, J Goudable, D Chassard, B Allaouchiche |
Journal | British journal of anaesthesia
(Br J Anaesth)
Vol. 100
Issue 1
Pg. 55-65
(Jan 2008)
ISSN: 1471-6771 [Electronic] England |
PMID | 17982168
(Publication Type: Journal Article)
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Chemical References |
- Vasodilator Agents
- Nitroprusside
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Topics |
- Acid-Base Equilibrium
(drug effects)
- Animals
- Disease Models, Animal
- Drug Evaluation, Preclinical
(methods)
- Female
- Ileum
(blood supply)
- Intestinal Mucosa
(blood supply)
- Liver Circulation
(drug effects)
- Microcirculation
(drug effects)
- Nitroprusside
(pharmacology)
- Regional Blood Flow
(drug effects)
- Respiration, Artificial
- Shock, Septic
(physiopathology, therapy)
- Splanchnic Circulation
(drug effects)
- Sus scrofa
- Vasodilator Agents
(pharmacology)
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