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Improving the prognosis of patients after radical cystectomy. Part II: the role of perioperative chemotherapy.

AbstractIn this review we analyse the current status of perioperative systemic chemotherapy in the treatment of transitional cell carcinoma (TCC) of the bladder; instead of summarizing each neoadjuvant or adjuvant clinical trial we focus on the advantages and disadvantages of both strategies on the basis of theoretical considerations, and outline a rationale for a better design of future studies to confirm the efficacy of perioperative chemotherapy in TCC.
AuthorsHenrik Suttmann, Jörn Kamradt, Jan Lehmann, Michael Stöckle (Affiliation: Department of Urology and Paediatric Urology, Saarland University Hospital, Homburg/Saar, Germany. henrik.suttmann at uniklinikum-saarland.de)
JournalBJU international (BJU Int) Vol. 100 Issue 6 Pg. 1225-8 (Dec 2007) ISSN: 1464-410X England
PMID17979921 (Publication Type: Journal Article, Review)
Topics
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Carcinoma, Transitional Cell (drug therapy, therapy)
  • Chemotherapy, Adjuvant
  • Cystectomy
  • Humans
  • Perioperative Care (methods)
  • Prognosis
  • Treatment Outcome
  • Urinary Bladder Neoplasms (drug therapy, therapy)