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Resolution of endometrial hyperplasia with adjuvant anastrozole treatment in postmenopausal breast cancer: a case report.

AbstractBACKGROUND:
Endometrial hyperplasia in patients with a history of breast cancer presents a therapeutic dilemma. The standard conservative therapy for hyperplasia, high-dose progestins, is contraindicated in breast cancer. Anastrozole, an aromatase inhibitor, is becoming first-line adjuvant therapy for breast cancer in postmenopausal women and may have protective effects on the endometrium.
CASE:
A 51-year-old, obese woman with a history of breast cancer presented with a 2-day history of heavy postmenopausal bleeding. Endometrial biopsy demonstrated simple hyperplasia without cellular atypia. After consultation with the patient's oncologist, the patient received adjuvant anastrozole therapy for the breast cancer; it led to resolution of the endometrial hyperplasia.
CONCLUSION:
Adjuvant therapy with anastrozole may be beneficial in resolving endometrial hyperplasia in patients with breast cancer.
AuthorsSarah E Stilwill, Brian C Cooper
JournalThe Journal of reproductive medicine (J Reprod Med) Vol. 52 Issue 10 Pg. 979-80 (Oct 2007) ISSN: 0024-7758 [Print] United States
PMID17977182 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Aromatase Inhibitors
  • Nitriles
  • Triazoles
  • Anastrozole
Topics
  • Anastrozole
  • Aromatase Inhibitors (therapeutic use)
  • Breast Neoplasms (complications, drug therapy)
  • Chemotherapy, Adjuvant
  • Endometrial Hyperplasia (complications, drug therapy)
  • Female
  • Humans
  • Middle Aged
  • Nitriles (therapeutic use)
  • Postmenopause
  • Treatment Outcome
  • Triazoles (therapeutic use)
  • Uterine Hemorrhage (etiology)

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