Abstract | BACKGROUND: Sickle hemoglobinopathies are among the most prevalent genetic disorders in the United States. Sickle cell trait ( hemoglobin AS) is the most common genotype and has traditionally been considered a benign condition. Systemic and ocular complications are seen infrequently in patients with sickle cell trait. In the presence of concomitant systemic diseases or trauma, however, marked retinopathy can occur. The presence of retinopathy in patients with sickle cell trait necessitates a comprehensive medical workup, including serologic testing to rule out systemic conditions. CASE REPORTS: CONCLUSION:
Sickle cell disease remains a major public health concern because of its associated significant morbidity and mortality. Sickle cell trait is considered benign in a healthy patient. However, under conditions of stress, concomitant systemic diseases, or trauma leading to hypoxia, sickle cell trait can become a pathologic risk factor.
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Authors | Sherrol A Reynolds, Eulogio Besada, Christine Winter-Corella |
Journal | Optometry (St. Louis, Mo.)
(Optometry)
Vol. 78
Issue 11
Pg. 582-7
(Nov 2007)
ISSN: 1529-1839 [Print] United States |
PMID | 17976620
(Publication Type: Case Reports, Journal Article)
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Topics |
- Adult
- Aortic Aneurysm, Thoracic
(complications)
- Female
- Fibrosis
- Humans
- Hypercholesterolemia
(complications)
- Hypertension
(complications)
- Male
- Middle Aged
- Retinal Diseases
(etiology, pathology)
- Retinal Hemorrhage
(complications)
- Sickle Cell Trait
(complications)
- Stroke
(complications)
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