Abstract |
The antinociceptive effect of the limonexic acid isolate of Raulinoa echinata Cowan in four models of pain in mice is described. When evaluated against acetic acid-induced abdominal constrictions, limonexic acid (10, 30 and 60 mg kg(-1), i.p.) produced dose-related inhibition of the number of constrictions, with a mean ID50 value of 43 (2.3-79) micromol kg(-1), and was more potent than some standard drugs. In the formalin test, limonexic acid inhibited both the first and second phases of formalin-induced pain. Furthermore, the effect was more pronounced in the second phase, with a mean ID50 value of 13.66 (9.35-19.61) micromol kg(-1), and had a pharmacological profile that was similar to standard drugs such as acetaminophen and acetyl salicylic acid. Limonexic acid also produced dose-related inhibition of glutamate- and capsaicin-induced pain, with mean ID50 values of 11.67 (8.51-16.0) micromol kg(-1) and 47.17 (36.51-60.93) micromol kg(-1), respectively. The mechanism of action is not completely understood, but seems to involve direct interaction with the GABAergic and nitroxidergic pathways.
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Authors | Maique W Biavatti, Rosângela Westerlon, Cristiani Burger, Ticiana Camila Mora, Márcia Maria De Souza |
Journal | The Journal of pharmacy and pharmacology
(J Pharm Pharmacol)
Vol. 59
Issue 11
Pg. 1573-81
(Nov 2007)
ISSN: 0022-3573 [Print] England |
PMID | 17976270
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Analgesics
- Limonins
- Plant Extracts
- limonexic acid
- Acetaminophen
- gamma-Aminobutyric Acid
- Aspirin
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Topics |
- Acetaminophen
(administration & dosage, pharmacology)
- Analgesics
(administration & dosage, pharmacology)
- Animals
- Aspirin
(administration & dosage, pharmacology)
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Inhibitory Concentration 50
- Limonins
(administration & dosage, pharmacology)
- Male
- Mice
- Nitrergic Neurons
(drug effects, metabolism)
- Pain
(drug therapy)
- Pain Measurement
- Phytotherapy
- Plant Extracts
- Plant Roots
- Plant Stems
- Rutaceae
(chemistry)
- gamma-Aminobutyric Acid
(drug effects, metabolism)
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