| Abstract | OBJECTIVE: To investigate the value of 18F-FDG PET-CT in detecting metastatic lymph node and radiation planning for patient with non-small-cell lung cancer (NSCLC). METHODS: The data of 58 NSCLC patients were retrospectively analyzed. Preoperatively, Both 18F-FDG PET-CT and CT scan were performed for all patients. Blinded interpretation of these images was then carried out. The gross tumor volume defined by radiation oncologist based on imaging results of either PET-CT or CT alone was compared with pathological results eventually. RESULTS: The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of detecting metastatic lymph node in the mediastinum was 56.0%, 54.2%, 54.8%, 38.9%, 70.3% by CT alone, and 88.0%, 85.4%, 86.3%, 75.9%, 93.2% by PET-CT, respectively. There was a statisticalty significant difference between two methods(P < 0.05). However, statisticalty no significant difference in detecting hilar lymph nodes was observed. The radiation target volume defined by CT was identical to that by PET-CT in 31(53.5%) cases, but changed in the other 27 (46.5%) cases when 18F-FDG PET data was added. The accuracy was 75.9% in detecting metastatic lymph nodes in the radiation target volume defined by PET-CT, while it was much lower by CT alone (48.3%) with a statistically significant difference between two methods (P < 0.05). CONCLUSION: 18F-FDG PET-CT is more accurate than CT alone in assessment of mediastinal lymph nodes for NSCLC patients. It may be recommended as a method in defining the radiation target volume. |
| Authors | Lan-Ping Liu, Jin-Ming Yu, Hong-Bo Guo, Zheng Fu, An-Qin Han, Guo-Ren Yang
(Affiliation: Department of Radiation Oncology, Shandong Cancer Hospital, Jinan 250117, China.)
|
| Journal | Zhonghua zhong liu za zhi [Chinese journal of oncology]
(Zhonghua Zhong Liu Za Zhi)
Vol. 29
Issue 6
Pg. 453-6
(Jun 2007)
ISSN: 0253-3766 China |
| PMID | 17974282
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Radiopharmaceuticals
- Fluorodeoxyglucose F18
|
| Topics |
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Non-Small-Cell Lung
(pathology, radionuclide imaging, radiotherapy)
- Female
- Fluorodeoxyglucose F18
(diagnostic use)
- Humans
- Lung Neoplasms
(pathology, radionuclide imaging, radiotherapy)
- Lymph Nodes
(pathology, radiation effects, radionuclide imaging)
- Lymphatic Metastasis
- Male
- Mediastinum
(radiation effects, radionuclide imaging)
- Middle Aged
- Positron-Emission Tomography
(methods)
- Radiopharmaceuticals
(diagnostic use)
- Retrospective Studies
- Tomography, X-Ray Computed
|
