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Natural antioxidant pedicularioside G inhibits angiogenesis and tumourigenesis in vitro and in vivo.

Abstract
Pedicularioside G is a new compound of phenylpropanoid glycosides, isolated from Pedicularis striata in our laboratory. Pedicularioside G inhibited two major angiogenic responses, human umbilical vein endothelial cell proliferation and migration, as well as neovascularization in a chicken embryo chorioallantoic membrane model. In addition, pedicularioside G inhibited human hepatoma cells proliferation and migration in vitro along with transplanting tumour formation and growth in a chicken embryo chorioallantoic membrane model. So pedicularioside G has anti-angiogenic, antitumour growth, antimetastatic and antitumoural effects. Pedicularioside G also remarkably reduced reactive oxygen species level in both vein endothelial cells and hepatoma cells in a concentration-dependent manner. These results suggest that the anti-angiogenic and antitumoural effects of pedicularioside G might partially attribute to its antioxidative activity.
AuthorsPing Mu, Xue Gao, Zhong-Jian Jia, Rong-Liang Zheng
JournalBasic & clinical pharmacology & toxicology (Basic Clin Pharmacol Toxicol) Vol. 102 Issue 1 Pg. 30-4 (Jan 2008) ISSN: 1742-7843 [Electronic] England
PMID17973903 (Publication Type: Journal Article)
Chemical References
  • Angiogenesis Inhibitors
  • Antioxidants
  • Drugs, Chinese Herbal
  • Glucosides
  • Iridoid Glucosides
  • Iridoids
  • Plant Extracts
  • Reactive Oxygen Species
  • pedicularioside
Topics
  • Angiogenesis Inhibitors (chemistry, pharmacology)
  • Animals
  • Antioxidants (chemistry, pharmacology)
  • Carcinoma, Hepatocellular (drug therapy, pathology)
  • Cell Line, Tumor
  • Cell Movement (drug effects)
  • Cell Proliferation (drug effects)
  • Chick Embryo
  • Chorioallantoic Membrane (blood supply)
  • Dose-Response Relationship, Drug
  • Drug Screening Assays, Antitumor
  • Drugs, Chinese Herbal (chemistry, pharmacology)
  • Endothelium, Vascular (drug effects, pathology)
  • Glucosides (chemistry, pharmacology)
  • Humans
  • In Vitro Techniques
  • Iridoid Glucosides
  • Iridoids (chemistry, pharmacology)
  • Liver Neoplasms (drug therapy, pathology)
  • Neovascularization, Pathologic (drug therapy)
  • Pedicularis (chemistry)
  • Plant Extracts (chemistry, pharmacology)
  • Reactive Oxygen Species (metabolism)

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