Abstract |
Pedicularioside G is a new compound of phenylpropanoid glycosides, isolated from Pedicularis striata in our laboratory. Pedicularioside G inhibited two major angiogenic responses, human umbilical vein endothelial cell proliferation and migration, as well as neovascularization in a chicken embryo chorioallantoic membrane model. In addition, pedicularioside G inhibited human hepatoma cells proliferation and migration in vitro along with transplanting tumour formation and growth in a chicken embryo chorioallantoic membrane model. So pedicularioside G has anti-angiogenic, antitumour growth, antimetastatic and antitumoural effects. Pedicularioside G also remarkably reduced reactive oxygen species level in both vein endothelial cells and hepatoma cells in a concentration-dependent manner. These results suggest that the anti-angiogenic and antitumoural effects of pedicularioside G might partially attribute to its antioxidative activity.
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Authors | Ping Mu, Xue Gao, Zhong-Jian Jia, Rong-Liang Zheng |
Journal | Basic & clinical pharmacology & toxicology
(Basic Clin Pharmacol Toxicol)
Vol. 102
Issue 1
Pg. 30-4
(Jan 2008)
ISSN: 1742-7843 [Electronic] England |
PMID | 17973903
(Publication Type: Journal Article)
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Chemical References |
- Angiogenesis Inhibitors
- Antioxidants
- Drugs, Chinese Herbal
- Glucosides
- Iridoid Glucosides
- Iridoids
- Plant Extracts
- Reactive Oxygen Species
- pedicularioside
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Topics |
- Angiogenesis Inhibitors
(chemistry, pharmacology)
- Animals
- Antioxidants
(chemistry, pharmacology)
- Carcinoma, Hepatocellular
(drug therapy, pathology)
- Cell Line, Tumor
- Cell Movement
(drug effects)
- Cell Proliferation
(drug effects)
- Chick Embryo
- Chorioallantoic Membrane
(blood supply)
- Dose-Response Relationship, Drug
- Drug Screening Assays, Antitumor
- Drugs, Chinese Herbal
(chemistry, pharmacology)
- Endothelium, Vascular
(drug effects, pathology)
- Glucosides
(chemistry, pharmacology)
- Humans
- In Vitro Techniques
- Iridoid Glucosides
- Iridoids
(chemistry, pharmacology)
- Liver Neoplasms
(drug therapy, pathology)
- Neovascularization, Pathologic
(drug therapy)
- Pedicularis
(chemistry)
- Plant Extracts
(chemistry, pharmacology)
- Reactive Oxygen Species
(metabolism)
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