Porphyria cutanea tarda as rare cutaneous manifestation of hepatic metastases treated with interferon.

Abstract

A 53-year-old woman with blistering on the hands was diagnosed with porphyria cutanea tarda (PCT). At that time, she was treated with interferon for liver metastasis of a pancreas tumor since 7 years. Although apparently rare, PCT has been described as possible cutaneous manifestation both of hepatic tumors and interferon treatment. Further, PCT can also be exacerbated by hepatitis C virus infection, alcohol, estrogens, HFE gene mutations predisposing for hereditary hemochromatosis, hexachlorobenzene, and 2,3,7,8-tetrachlorodibenzo-p-dioxin. Therefore, it is important to keep in mind that the manifestation of PCT may be associated with distinct precipitating factors, which are briefly discussed here.

• Authors: Klara Mosterd, Charles Henquet, Jorge Frank
• Journal: International journal of dermatology (Int J Dermatol) Vol. 46 Suppl 3 Pg. 19-21 (Nov 2007) ISSN: 1365-4632 [Electronic] England
• PMID: 17973882 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents
• Interferon alpha-2
• Interferon-alpha
• Recombinant Proteins

Topics

• Adenocarcinoma (complications, drug therapy, secondary)
• Antineoplastic Agents (therapeutic use)
• Female
• Humans
• Interferon alpha-2
• Interferon-alpha (therapeutic use)
• Liver Neoplasms (complications, drug therapy, secondary)
• Middle Aged
• Porphyria Cutanea Tarda (diagnosis, etiology)
• Recombinant Proteins