Management of late recurrence of a low-grade endometrial stromal sarcoma (LGESS): treatment with letrozole.

Abstract

Low grade endometrial stromal sarcoma (LGESS) is a rare disease. LGESS usually expresses steroidal receptors and is regarded to be hormone-sensitive. Due to the rarity of the tumor, only few case series have been published so far. Here, we report the case of a 36-year-old woman who underwent an abdominal hysterectomy with bilateral salpingo-oophorectomy and adjuvant radiotherapy for a G1 LGESS in 1991. Twelve years later she presented to us with pelvic and peritoneal masses. The patient was treated with letrozole achieving a partial response which is lasting 39 months. Treatment is ongoing. Aromatase inhibitors represent an interesting treatment option for LGESS.

• Authors: K Krauss, C Bachmann, J T Hartmann, K Siegmann, K Sotlar, D Wallwiener, J Huober
• Journal: Anticancer research (Anticancer Res) 2007 Sep-Oct Vol. 27 Issue 5B Pg. 3477-80 ISSN: 0250-7005 [Print] Greece
• PMID: 17972504 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents
• Nitriles
• Triazoles
• Letrozole

Topics

• Adult
• Antineoplastic Agents (therapeutic use)
• Endometrial Stromal Tumors (drug therapy, pathology, prevention & control)
• Female
• Humans
• Letrozole
• Muscle Neoplasms (secondary)
• Nitriles (therapeutic use)
• Psoas Muscles (pathology)
• Radiography, Abdominal
• Recurrence
• Tomography, X-Ray Computed
• Triazoles (therapeutic use)