Hydrophobic polycationic coatings inactivate wild-type and zanamivir- and/or oseltamivir-resistant human and avian influenza viruses.

Abstract

Glass slides painted with the hydrophobic long-chained polycation N,N-dodecyl,methyl-polyethylenimine (N,N-dodecyl,methyl-PEI) are highly lethal to waterborne influenza A viruses, including not only wild-type human and avian strains but also their neuraminidase mutants resistant to currently used anti-influenza drugs.

• Authors: Jayanta Haldar, Jianzhu Chen, Terrence M Tumpey, Larisa V Gubareva, Alexander M Klibanov
• Journal: Biotechnology letters (Biotechnol Lett) Vol. 30 Issue 3 Pg. 475-9 (Mar 2008) ISSN: 0141-5492 [Print] Netherlands
• PMID: 17972018 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Antiviral Agents
• Enzyme Inhibitors
• N,N-dodecyl,methyl-polyethylenimine
• Oseltamivir
• Polyethyleneimine
• Zanamivir

Topics

• Animals
• Antiviral Agents (pharmacology)
• Cell Line
• Drug Resistance, Viral
• Enzyme Inhibitors (pharmacology)
• Humans
• Influenza A virus (drug effects)
• Oseltamivir (pharmacology)
• Polyethyleneimine (analogs & derivatives, pharmacology)
• Zanamivir (pharmacology)