| Abstract | We evaluated the efficacy of epirubicin in a phase II trial in breast cancer, as well as its cardiac toxicity. The study was carried out on 40 female patients with advanced, metastatic, or recurrent breast cancer. The patients were grouped into two groups: group I received 30 mg/m2 epirubicin weekly, and group II 90 mg/m2 epirubicin every 3 weeks. Cardiac monitoring was by ECG, roentgenography, echocardiography and endomyocardial biopsies. Clinical results were 35.3% overall response in group I, and 50% overall response in group II. No untoward cardiac toxicities were encountered. We conclude that epirubicin is an effective agent in breast cancer with relatively little cardiac toxicity. |
| Authors | N G el Mawla, M R Hamza, A el Khodari, H Khaled, R Gaafar, H el Zawahry, A abdel Wareth, M D Dardir, N Habboubi
(Affiliation: National Cancer Institute, Department of Medical Oncology, Cairo, Egypt.)
|
| Journal | Anti-cancer drugs
(Anticancer Drugs)
Vol. 2
Issue 4
Pg. 371-4
(Aug 1991)
ISSN: 0959-4973 ENGLAND |
| PMID | 1797193
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
|
| Chemical References |
|
| Topics |
- Adult
- Breast Neoplasms
(drug therapy)
- Drug Evaluation
- Echocardiography
- Electrocardiography
- Epirubicin
(administration & dosage, adverse effects, therapeutic use)
- Female
- Heart Diseases
(chemically induced, pathology, radiography)
- Humans
- Middle Aged
- Myocardium
(pathology)
- Neoplasm Metastasis
|
