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Reduced cerebral fluoro-L-dopamine uptake in adult patients suffering from phenylketonuria.

Abstract
Deficiency of phenylalanine hydroxylase activity in phenylketonuria (PKU) causes an excess of phenylalanine (Phe) throughout the body, predicting impaired synthesis of catecholamines in the brain. To test this hypothesis, we used positron emission tomography (PET) to measure the utilization of 6-[18F]fluoro-L-DOPA [corrected] (FDOPA) in the brain of adult patients suffering from PKU and in healthy controls. Dynamic 2-h long FDOPA emission recordings were obtained in seven adult PKU patients (five females, two males; age: 21 to 27 years) with elevated serum Phe levels, but lacking neurologic deficits. Seven age-matched, healthy volunteers were imaged under identical conditions. The utilization of FDOPA in striatum was calculated by linear graphical analysis (k3S, min(-1)), with cerebellum serving as a nonbinding reference region. The time to peak activity in all brain time-radioactivity curves was substantially delayed in the PKU patients relative to the control group. The mean magnitude of k3S in the striatum of the PKU patients (0.0052+/-0.0004 min(-1)) was significantly lower than in the control group (0.0088+/-0.0009 min(-1)) (P<0.001). There was no significant correlation between individual serum Phe levels and k3S. The unidirectional clearance of FDOPA to brain was impaired in adult patients suffering from PKU, presumably reflecting the competitive inhibition of the large neutral amino acid carrier by Phe. Assuming this competition to be spatially uniform, the relationship between striatum and cerebellum time-activity curves additionally suggests inhibition of DOPA efflux, possibly also due to competition from Phe. The linear graphical analysis shows reduced k3S in striatum, indicating reduced DOPA decarboxylase activity.
AuthorsChristian Landvogt, Eugen Mengel, Peter Bartenstein, Hans Georg Buchholz, Mathias Schreckenberger, Thomas Siessmeier, Armin Scheurich, Reinhold Feldmann, Josef Weglage, Paul Cumming, Fred Zepp, Kurt Ullrich
JournalJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (J Cereb Blood Flow Metab) Vol. 28 Issue 4 Pg. 824-31 (Apr 2008) ISSN: 0271-678X [Print] United States
PMID17971791 (Publication Type: Journal Article)
Chemical References
  • Fluorine Radioisotopes
  • Dihydroxyphenylalanine
Topics
  • Adult
  • Corpus Striatum (metabolism)
  • Dihydroxyphenylalanine (metabolism)
  • Female
  • Fluorine Radioisotopes (metabolism)
  • Humans
  • Male
  • Phenylketonurias (physiopathology)
  • Positron-Emission Tomography

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