Comparison of the effectiveness of geranylgeranylacetone with cimetidine in gastritis patients with dyspeptic symptoms and gastric lesions: a randomized, double-blind trial in Japan.

Abstract

BACKGROUND AND AIM:

Controversy remains regarding the treatment of choice for chronic gastritis patients with dyspeptic symptoms when Helicobacter pylori eradication is not indicated or fails for their gastric lesions. A multicenter, randomized, double-blind trial was performed to compare the effectiveness of geranylgeranylacetone (GGA), a mucoprotective drug, against cimetidine (CIT), an H(2)-receptor antagonist, on the treatment of erosions and petechial hemorrhage in H. pylori-infected patients with dyspeptic symptoms.

METHODS:

128 H. pylori-positive gastritis patients with mucosal erosions and/or petechial hemorrhage were randomized to receive 150 mg GGA t.i.d. or 400 mg CIT b.i.d. for 2 weeks. Improvement and cure rates on endoscopic findings, symptom disappearance rates, and changes in mucosal neutrophil infiltration were compared.

RESULTS:

Endoscopic improvement rates were significantly higher in the GGA group (n = 50) than in the CIT group (n = 54; 86.0 vs. 64.8%, p = 0.014). Endoscopic cure rates were also significantly higher for GGA than for CIT (80.0 vs. 55.6%, p = 0.012). Symptom disappearance rates were 52.0% for GGA and 42.6% for CIT, but the difference was not significant. There was also no significant difference in mucosal neutrophil infiltration between the groups.

CONCLUSION:

GGA treatment appears to be more effective than CIT for chronic gastritis-associated erosion and petechial hemorrhage.

• Authors: Choitsu Sakamoto, Kazuei Ogoshi, Katsunori Saigenji, Rintarou Narisawa, Hiroshi Nagura, Tetsuya Mine, Masahiro Tada, Eiji Umegaki, Takama Maekawa, Ryuichiro Maekawa, Kazuhiro Maeda
• Journal: Digestion (Digestion) Vol. 75 Issue 4 Pg. 215-24 ( 2007) ISSN: 1421-9867 [Electronic] Switzerland
• PMID: 17971666 (Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: (c) 2007 S. Karger AG, Basel

Chemical References

• Anti-Ulcer Agents
• Diterpenes
• Cimetidine
• geranylgeranylacetone

Topics

• Anti-Ulcer Agents (therapeutic use)
• Cimetidine (therapeutic use)
• Diterpenes (therapeutic use)
• Double-Blind Method
• Dyspepsia (drug therapy, microbiology)
• Female
• Gastritis (drug therapy, microbiology)
• Gastroscopy
• Helicobacter Infections (drug therapy)
• Helicobacter pylori
• Humans
• Japan
• Male
• Middle Aged
• Statistics, Nonparametric
• Treatment Outcome