Abstract | BACKGROUND: METHODS: In a population-based prospective nested case-control study, the relationships between ESR1 polymorphisms (c.454-397T>C and c.454-351A>G) and ischemic stroke and ICH were examined in univariate and multivariate models using conditional logistic regression, which included established risk factors.Definitive first-ever stroke events (n = 388), including ischemic stroke (n = 320), ICH (n = 61), and unspecified stroke (n = 7) cases, and controls without cardiovascular disease (n = 773), matched for age, sex, and geographical region were included. RESULTS: Carriers of the c.454-397T/T genotype had a significantly (p = 0.017) increased risk of ICH (OR 2.31, 95% CI 1.16-4.60) in a univariate analysis. This association persisted (OR 3.94, 95% CI 1.54-10.03), after adjustment for stroke risk determinants. Carriers of c.454-397T/T or c.454-397T/C genotypes had significantly (p = 0.002 and p = 0.004, respectively) higher mean systolic blood pressure (SBP), than carriers of c.454-397C/C, and a similar relationship was observed for diastolic blood pressure (DBP). The combinations of c.454-397T/T genotype and hypertension (OR 21.46, 95% CI 5.20-88.51), or high SBP (OR 18.17, 95% CI 4.91-67.31) or DBP (OR 11.94, 95% CI 3.75-38.03), were strongly associated with increased risk of ICH. CONCLUSIONS: In this population,the c.454-397T/T genotype associates with first-ever ICH, particularly in combination with hypertension. This implies that alterations in ER alpha-mediated signaling may be involved in the pathophysiology of this disease, with a putative impact on primary prevention.
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Authors | Magnus Strand, Ingegerd Söderström, Per-Gunnar Wiklund, Göran Hallmans, Lars Weinehall, Stefan Söderberg, Tommy Olsson |
Journal | Cerebrovascular diseases (Basel, Switzerland)
(Cerebrovasc Dis)
Vol. 24
Issue 6
Pg. 500-8
( 2007)
ISSN: 1421-9786 [Electronic] Switzerland |
PMID | 17971628
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | (c) 2007 S. Karger AG, Basel. |
Chemical References |
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Topics |
- Aged
- Base Sequence
- Blood Pressure
(genetics)
- Brain Ischemia
(complications)
- Case-Control Studies
- Cerebral Hemorrhage
(etiology, genetics)
- Estrogen Receptor alpha
(genetics)
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Heterozygote
- Humans
- Hypertension
(complications)
- Male
- Middle Aged
- Molecular Sequence Data
- Polymorphism, Genetic
- Prospective Studies
- Stroke
(etiology, genetics)
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