| Abstract | Gentamicin is an aminoglycoside with a wide spectrum of antibacterial activity. However, as a highly water-soluble drug, it penetrates cells poorly. This constitutes a particularly important drawback for treating intracellular bacterial infections. This major hurdle may be solved by the use of vectors to deliver and target bioactive agents to the intracellular sites of infection. Thus, in the case of antimicrobials, drug delivery systems may help to increase their therapeutic index in intracellular locations. The development and evolution of pharmaceutical forms of gentamicin for the parenteral treatment of intracellular pathogens is reviewed in this paper. |
| Authors | Carlos Gamazo, Sandra Prior, María Concepción Lecároz, Ana Isabel Vitas, Miguel Angel Campanero, Guiomar Pérez, David Gonzalez, María Jose Blanco-Prieto
(Affiliation: University of Navarra, Department of Microbiology, 31080 Pamplona, Spain. cgamazo at unav.es)
|
| Journal | Expert opinion on drug delivery
(Expert Opin Drug Deliv)
Vol. 4
Issue 6
Pg. 677-88
(Nov 2007)
ISSN: 1742-5247 England |
| PMID | 17970669
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
|
| Chemical References |
- Drug Carriers
- Gentamicins
- Liposomes
|
| Topics |
- Animals
- Bacterial Infections
(drug therapy)
- Drug Carriers
(chemical synthesis, chemistry)
- Drug Delivery Systems
(methods)
- Gentamicins
(administration & dosage, chemistry, therapeutic use)
- Humans
- Infusions, Parenteral
- Liposomes
- Nanoparticles
(chemistry)
|
