Abstract | BACKGROUND: MATERIALS AND METHODS: Using immunohistochemistry, the levels of tumoral immunoreactivity for VEGFs in 105 nonmetastatic, lymphogenously-metastatic and haematogenously-metastatic CRC specimens were assessed. Statistical analysis was performed using Fisher's exact probability test. RESULTS:
VEGFR-1 immunoreactivity was positive in only 50% of the cases. However lack of expression of VEGFR-1 was significantly associated with lymphogenous and haematogenous metastases. VEGFR-2 and VEGFR-3 were expressed in all investigated specimens to varying degrees. Low levels of VEGFR-2 were significantly associated with distant metastases. No significant changes were detected in VEGFR-3 expression. CONCLUSION: Epithelial expression of VEGFR-1 and VEGFR-2 appear to have a protective effect against tumor aggressiveness in CRC.
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Authors | Nektaria Simiantonaki, Marios Taxeidis, Caren Jayasinghe, Charles James Kirkpatrick |
Journal | Anticancer research
(Anticancer Res)
2007 Sep-Oct
Vol. 27
Issue 5A
Pg. 3245-50
ISSN: 0250-7005 [Print] Greece |
PMID | 17970067
(Publication Type: Journal Article)
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Chemical References |
- Receptors, Vascular Endothelial Growth Factor
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Topics |
- Colorectal Neoplasms
(metabolism, pathology)
- Epithelial Cells
(metabolism, pathology)
- Humans
- Immunohistochemistry
- Neoplasm Metastasis
- Receptors, Vascular Endothelial Growth Factor
(biosynthesis)
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