Abstract | OBJECTIVE: METHODS: On the basis of epileptic model induced by pentylenetetrazol (PTZ), cognitive impairment model was induced by kindling epilepsy with PTZ everyday, which were then di-vided into the model-1 group, the CZD-1 group, the nimodipine-1 group, and those by injecting large dosage phenytoin sodium were divided into the model-2 group, the CZD-2 group and the nimodipine-2 group. Changes of pCREB protein in rat's hippocampus were detected using immunohistochemistry and Western blotting assay. RESULTS: The expression of pCREB was higher in the CZD-1 and nimodipine-1 group than in the model group, while it was significantly different in the CZD-2 and nimodipine-2 groups than in the model-2 group. CONCLUSION: CZD could relieve the cognitive dysfunction in the epileptic model rats induced by everyday PTZ kindling or by dilantin through increasing the pCREB expression.
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Authors | Juan He, Shi-Lei Ma |
Journal | Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
(Zhongguo Zhong Xi Yi Jie He Za Zhi)
Vol. 27
Issue 9
Pg. 819-21
(Sep 2007)
ISSN: 1003-5370 [Print] China |
PMID | 17969896
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cyclic AMP Response Element-Binding Protein
- Drugs, Chinese Herbal
- caoguo zhimu
- Phenytoin
- Pentylenetetrazole
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Topics |
- Animals
- Cognition Disorders
(chemically induced, prevention & control)
- Cyclic AMP Response Element-Binding Protein
(metabolism)
- Drugs, Chinese Herbal
(therapeutic use)
- Epilepsy
(chemically induced, drug therapy, metabolism)
- Hippocampus
(drug effects, metabolism, pathology)
- Kindling, Neurologic
(drug effects)
- Male
- Pentylenetetrazole
- Phenytoin
(adverse effects)
- Phosphorylation
- Phytotherapy
- Random Allocation
- Rats
- Rats, Sprague-Dawley
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