HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Enhanced anti-tumor effect of combination therapy with gemcitabine and apigenin in pancreatic cancer.

Abstract
Apigenin is a dietary flavonoid possessing therapeutic potential against cancers. This study was designed to investigate whether combination therapy with gemcitabine and apigenin enhanced anti-tumor efficacy in pancreatic cancer. In vitro, the combination treatment resulted in more growth inhibition and apoptosis through the down-regulation of NF-kappa B activity with suppression of Akt activation in pancreatic cancer cell lines (MiaPaca-2, AsPC-1). In vivo, the combination therapy augmented tumor growth inhibition through the down-regulation of NF-kappa B activity with the suppression of Akt in tumor tissue. The combination of gemcitabine and apigenin enhanced anti-tumor efficacy through Akt and NF-kappa B activity suppression and apoptosis induction.
AuthorsSang Hyub Lee, Ji Kon Ryu, Kyeung-Yeup Lee, Sang Myung Woo, Joo Kyung Park, Ji Won Yoo, Yong-Tae Kim, Yong Bum Yoon
JournalCancer letters (Cancer Lett) Vol. 259 Issue 1 Pg. 39-49 (Jan 18 2008) ISSN: 0304-3835 [Print] Ireland
PMID17967505 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antimetabolites, Antineoplastic
  • BAX protein, human
  • NF-kappa B
  • bcl-2-Associated X Protein
  • Deoxycytidine
  • Apigenin
  • Proto-Oncogene Proteins c-akt
  • Gemcitabine
Topics
  • Animals
  • Antimetabolites, Antineoplastic (administration & dosage)
  • Antineoplastic Combined Chemotherapy Protocols (pharmacology, therapeutic use)
  • Apigenin (administration & dosage)
  • Apoptosis (drug effects)
  • Cell Line, Tumor
  • Cell Proliferation (drug effects)
  • Deoxycytidine (administration & dosage, analogs & derivatives)
  • Dose-Response Relationship, Drug
  • Down-Regulation
  • Drug Synergism
  • Humans
  • Mice
  • NF-kappa B (metabolism)
  • Pancreatic Neoplasms (drug therapy, metabolism, pathology)
  • Proto-Oncogene Proteins c-akt (metabolism)
  • Xenograft Model Antitumor Assays
  • bcl-2-Associated X Protein (metabolism)
  • Gemcitabine

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: