Abstract | OBJECTIVE: METHODS: Sixty patients with acute myocardial infarction were randomized to receive trimetazidine (a loading dose of 60 mg followed by 20 mg 3 times daily) for 2 weeks (n = 32) or to be controls (n = 28). The loading dose was started early before the reperfusion therapy. Patients received intermittent ST-segment monitoring to assess the resolution of ST-segment deviation one hour after reperfusion therapy. Venous blood samples for measurement of malondialdehyde (MDA) and endothelin (ET-1) were taken immediately on admission and 1, 4, 8, 24 and 48 hours as well as 7 days after reperfusion. In-hospital and 3-months major adverse cardiac events were recorded. RESULTS: Blinded ST-segment analysis showed that there was a more marked return towards baseline one hour after reperfusion therapy in the trimetazidine group, than in the control group [change (7.14 +/- 3.50) mm vs (3.79 +/- 1.32) mm, P = 0.041]. The measurement of plasma MDA showed that, there was a significantly lower level in the trimetazidine group 4, 8, 24, 48 hours and 7 days after reperfusion (P < 0.05). The level of plasma ET-1 was significantly lower in the trimetazidine group 8 hours and 7 days after reperfusion (P < 0.05). There was no side effect due to trimetazidine. Clinical outcomes were similar between the two groups. CONCLUSIONS:
Trimetazidine is effective for the resolution of ST-segment elevation. The effect of trimetazidine against malondialdehyde and ET-1 formation suggested that it might be the mechanism of the myocardial protection.
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Authors | Xiao-dong Dong, Da-yi Hu, San-qing Jia, Lei Wang, Song-biao Yan |
Journal | Zhonghua nei ke za zhi
(Zhonghua Nei Ke Za Zhi)
Vol. 46
Issue 8
Pg. 633-6
(Aug 2007)
ISSN: 0578-1426 [Print] China |
PMID | 17967230
(Publication Type: English Abstract, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Endothelin-1
- Vasodilator Agents
- Malondialdehyde
- Trimetazidine
|
Topics |
- Aged
- Endothelin-1
(blood)
- Follow-Up Studies
- Humans
- Male
- Malondialdehyde
(blood)
- Middle Aged
- Myocardial Infarction
(blood, drug therapy, therapy)
- Myocardial Reperfusion
(methods)
- Trimetazidine
(therapeutic use)
- Vasodilator Agents
(therapeutic use)
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