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[Clinical study of trimetazidine for myocardial protection in acute myocardial infarction].

AbstractOBJECTIVE:
To assess the effect of trimetazidine as an adjunctive treatment to reperfusion therapy in acute myocardial infarction.
METHODS:
Sixty patients with acute myocardial infarction were randomized to receive trimetazidine (a loading dose of 60 mg followed by 20 mg 3 times daily) for 2 weeks (n = 32) or to be controls (n = 28). The loading dose was started early before the reperfusion therapy. Patients received intermittent ST-segment monitoring to assess the resolution of ST-segment deviation one hour after reperfusion therapy. Venous blood samples for measurement of malondialdehyde (MDA) and endothelin (ET-1) were taken immediately on admission and 1, 4, 8, 24 and 48 hours as well as 7 days after reperfusion. In-hospital and 3-months major adverse cardiac events were recorded.
RESULTS:
Blinded ST-segment analysis showed that there was a more marked return towards baseline one hour after reperfusion therapy in the trimetazidine group, than in the control group [change (7.14 +/- 3.50) mm vs (3.79 +/- 1.32) mm, P = 0.041]. The measurement of plasma MDA showed that, there was a significantly lower level in the trimetazidine group 4, 8, 24, 48 hours and 7 days after reperfusion (P < 0.05). The level of plasma ET-1 was significantly lower in the trimetazidine group 8 hours and 7 days after reperfusion (P < 0.05). There was no side effect due to trimetazidine. Clinical outcomes were similar between the two groups.
CONCLUSIONS:
Trimetazidine is effective for the resolution of ST-segment elevation. The effect of trimetazidine against malondialdehyde and ET-1 formation suggested that it might be the mechanism of the myocardial protection.
AuthorsXiao-dong Dong, Da-yi Hu, San-qing Jia, Lei Wang, Song-biao Yan
JournalZhonghua nei ke za zhi (Zhonghua Nei Ke Za Zhi) Vol. 46 Issue 8 Pg. 633-6 (Aug 2007) ISSN: 0578-1426 [Print] China
PMID17967230 (Publication Type: English Abstract, Journal Article, Randomized Controlled Trial)
Chemical References
  • Endothelin-1
  • Vasodilator Agents
  • Malondialdehyde
  • Trimetazidine
Topics
  • Aged
  • Endothelin-1 (blood)
  • Follow-Up Studies
  • Humans
  • Male
  • Malondialdehyde (blood)
  • Middle Aged
  • Myocardial Infarction (blood, drug therapy, therapy)
  • Myocardial Reperfusion (methods)
  • Trimetazidine (therapeutic use)
  • Vasodilator Agents (therapeutic use)

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